Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 18
UCP2 P55851 uncoupling protein 2 Transporter 1.5E-10 0.493 0.808 18
LPL P06858 lipoprotein lipase Enzyme 1.3E-09 0.474 0.808 16
NR1H4 Q96RI1 nuclear receptor subfamily 1 group H member 4 Nuclear receptor 9.4E-04 0.513 0.808 16
IRS1 P35568 insulin receptor substrate 1 2.4E-02 0.488 0.769 13
TFRC P02786 transferrin receptor Enzyme 7.0E-05 0.437 0.885 13
ATP5F1A P25705 ATP synthase F1 subunit alpha Transporter 1.00 0.604 0.731 11
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 11
MAPK8 P45983 mitogen-activated protein kinase 8 Kinase 1.00 0.397 0.885 10
ABCG5 Q9H222 ATP binding cassette subfamily G member 5 Transporter 3.1E-21 0.592 0.577 9
SIRT3 Q9NTG7 sirtuin 3 Epigenetic regulator 1.6E-04 0.488 0.731 9
DGAT2 Q96PD7 diacylglycerol O-acyltransferase 2 Enzyme 8.4E-12 0.686 0.423 7
ACO1 P21399 aconitase 1 Enzyme 3.8E-18 0.628 0.577 6
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 6
ADAMTS13 Q76LX8 ADAM metallopeptidase with thrombospondin type 1 motif 13 Enzyme 5.1E-15 0.496 0.769 6
IDE P14735 insulin degrading enzyme Enzyme 6.6E-03 0.604 0.577 6
IRS2 Q9Y4H2 insulin receptor substrate 2 0.99 0.535 0.654 6
RARRES2 Q99969 retinoic acid receptor responder 2 2.7E-05 0.519 0.731 6
SIRT2 Q8IXJ6 sirtuin 2 Epigenetic regulator 2.3E-08 0.510 0.769 6
SIRT6 Q8N6T7 sirtuin 6 Epigenetic regulator 3.9E-02 0.496 0.846 6
ABCG8 Q9H221 ATP binding cassette subfamily G member 8 Transporter 2.4E-20 0.573 0.538 5
ACADVL P49748 acyl-CoA dehydrogenase very long chain Enzyme 4.2E-15 0.653 0.654 5
CYP8B1 Q9UNU6 cytochrome P450 family 8 subfamily B member 1 2.1E-05 0.711 0.269 5
NR1H3 Q13133 nuclear receptor subfamily 1 group H member 3 Nuclear receptor 0.90 0.566 0.692 5