Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 89
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 88
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 84
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 83
LEP P41159 leptin 0.46 0.349 0.846 78
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 77
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 67
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 67
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 62
GSTT1 P30711 glutathione S-transferase theta 1 1.5E-04 0.393 0.923 55
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 53
MBL2 P11226 mannose binding lectin 2 Receptor 2.7E-03 0.390 0.846 53
CCR5 P51681 C-C motif chemokine receptor 5 (gene/pseudogene) G-protein coupled receptor 4.3E-10 0.398 0.885 49
F5 P12259 coagulation factor V Enzyme 5.9E-15 0.441 0.846 47
HLA-G P17693 major histocompatibility complex, class I, G 1.4E-11 0.461 0.769 46
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885 41
CYP1A1 P04798 cytochrome P450 family 1 subfamily A member 1 Enzyme 1.1E-17 0.436 0.846 40
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 40