Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 90
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 69
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 44
XDH P47989 xanthine dehydrogenase Enzyme 2.6E-22 0.529 0.846 38
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 32
CX3CL1 P78423 C-X3-C motif chemokine ligand 1 Signaling 0.61 0.478 0.808 27
CX3CR1 P49238 C-X3-C motif chemokine receptor 1 G-protein coupled receptor 6.1E-02 0.457 0.885 26
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 25
NGFR P08138 nerve growth factor receptor Receptor 9.8E-02 0.477 0.846 23
SERPINF1 P36955 serpin family F member 1 Enzyme modulator 7.8E-08 0.460 0.846 18
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885 18
BDKRB2 P30411 bradykinin receptor B2 G-protein coupled receptor 0.12 0.585 0.808 17
EDNRB P24530 endothelin receptor type B G-protein coupled receptor 9.2E-03 0.470 0.846 17
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 17
NR1H4 Q96RI1 nuclear receptor subfamily 1 group H member 4 Nuclear receptor 9.4E-04 0.513 0.808 16
EDNRA P25101 endothelin receptor type A G-protein coupled receptor 0.99 0.426 0.885 15
GRK2 P25098 G protein-coupled receptor kinase 2 Kinase 1.00 0.532 0.654 15
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885 14
DUSP1 P28562 dual specificity phosphatase 1 1.0E-02 0.491 0.808 13