Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 39
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 27
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 25
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 25
CTSB P07858 cathepsin B Enzyme 5.9E-11 0.457 0.846 22
NPPB P16860 natriuretic peptide B 9.9E-06 0.513 0.808 20
PTGS1 P23219 prostaglandin-endoperoxide synthase 1 Enzyme 6.2E-07 0.460 0.885 18
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 17
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 17
PLA2G4A P47712 phospholipase A2 group IVA Enzyme 6.0E-05 0.496 0.846 16
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 15
BGLAP P02818 bone gamma-carboxyglutamate protein 4.6E-08 0.462 0.846 13
EPAS1 Q99814 endothelial PAS domain protein 1 Transcription factor 0.60 0.454 0.731 12
RPS6KB1 P23443 ribosomal protein S6 kinase B1 Kinase 0.97 0.511 0.731 10
TNC P24821 tenascin C 1.3E-07 0.433 0.846 10
SLC34A1 Q06495 solute carrier family 34 member 1 Transporter 8.9E-27 0.619 0.423 9
LRP2 P98164 LDL receptor related protein 2 1.00 0.491 0.846 8
LRP5 O75197 LDL receptor related protein 5 0.51 0.485 0.846 4
HDAC6 Q9UBN7 histone deacetylase 6 Epigenetic regulator 1.00 0.465 0.846 3