Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 90
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 40
ANXA1 P04083 annexin A1 1.2E-07 0.442 0.885 30
CX3CL1 P78423 C-X3-C motif chemokine ligand 1 Signaling 0.61 0.478 0.808 27
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 27
CX3CR1 P49238 C-X3-C motif chemokine receptor 1 G-protein coupled receptor 6.1E-02 0.457 0.885 26
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 25
CD40LG P29965 CD40 ligand Signaling 0.72 0.414 0.846 24
CAV1 Q03135 caveolin 1 Enzyme modulator 8.3E-03 0.388 0.885 18
HMGCR P04035 3-hydroxy-3-methylglutaryl-CoA reductase 1.00 0.529 0.692 18
PTGS1 P23219 prostaglandin-endoperoxide synthase 1 Enzyme 6.2E-07 0.460 0.885 18
AIF1 P55008 allograft inflammatory factor 1 Calcium-binding protein 1.9E-06 0.521 0.808 17
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 17
EPO P01588 erythropoietin 1.1E-02 0.381 0.885 16
CD40 P25942 CD40 molecule 0.85 0.396 0.846 14
IL5 P05113 interleukin 5 5.7E-03 0.437 0.846 14
RHOA P61586 ras homolog family member A Enzyme modulator 0.60 0.502 0.808 14
MMP7 P09237 matrix metallopeptidase 7 Enzyme 1.0E-09 0.446 0.885 13
EPAS1 Q99814 endothelial PAS domain protein 1 Transcription factor 0.60 0.454 0.731 12