Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 33
LEP P41159 leptin 0.46 0.349 0.846 28
CCN2 P29279 cellular communication network factor 2 Signaling 5.0E-04 0.399 0.846 26
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 26
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 23
FASLG P48023 Fas ligand Signaling 0.18 0.430 0.885 20
HSPD1 P10809 heat shock protein family D (Hsp60) member 1 0.99 0.432 0.808 18
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885 18
DRD1 P21728 dopamine receptor D1 G-protein coupled receptor 0.96 0.529 0.808 16
GRK2 P25098 G protein-coupled receptor kinase 2 Kinase 1.00 0.532 0.654 15
HSF1 Q00613 heat shock transcription factor 1 Transcription factor 0.75 0.507 0.769 12
PENK P01210 proenkephalin Signaling 2.1E-04 0.560 0.808 11
HSPA8 P11142 heat shock protein family A (Hsp70) member 8 1.00 0.553 0.808 9
PTN P21246 pleiotrophin Signaling 7.5E-03 0.515 0.808 9
DDC P20711 dopa decarboxylase 3.8E-08 0.535 0.769 8
DBN1 Q16643 drebrin 1 Cellular structure 1.00 0.633 0.538 6
GRK3 P35626 G protein-coupled receptor kinase 3 Kinase 0.71 0.621 0.731 5
HSPA4 P34932 heat shock protein family A (Hsp70) member 4 1.00 0.394 0.923 5
OPTN Q96CV9 optineurin 5.9E-18 0.548 0.808 5
SLC18A2 Q05940 solute carrier family 18 member A2 Transporter 7.6E-02 0.554 0.769 5
HTR1A P08908 5-hydroxytryptamine receptor 1A G-protein coupled receptor 0.20 0.522 0.846 4
PRKN O60260 parkin RBR E3 ubiquitin protein ligase Enzyme 6.9E-07 0.431 0.846 4
SNCA P37840 synuclein alpha Transporter 0.88 0.427 0.885 4