Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 60
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 45
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 41
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
BAD Q92934 BCL2 associated agonist of cell death 4.6E-03 0.553 0.769 30
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 25
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885 24
FASLG P48023 Fas ligand Signaling 0.18 0.430 0.885 20
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 19
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 18
BCL2L1 Q07817 BCL2 like 1 Signaling 0.94 0.493 0.885 17
MMP13 P45452 matrix metallopeptidase 13 Enzyme 7.9E-18 0.452 0.923 17
HRH3 Q9Y5N1 histamine receptor H3 G-protein coupled receptor 4.1E-02 0.647 0.462 12
COL18A1 P39060 collagen type XVIII alpha 1 chain 1.7E-10 0.449 0.808 11
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885 11
TEK Q02763 TEK receptor tyrosine kinase Kinase 1.00 0.462 0.692 11
MUC5AC P98088 mucin 5AC, oligomeric mucus/gel-forming Enzyme modulator 1.0E-08 0.483 0.808 10
ANGPT1 Q15389 angiopoietin 1 Signaling 0.95 0.446 0.808 8
CFTR P13569 CF transmembrane conductance regulator Ion channel 2.2E-58 0.424 0.885 8