Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 72
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 62
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 60
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 46
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885 43
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 42
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
BAD Q92934 BCL2 associated agonist of cell death 4.6E-03 0.553 0.769 30
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 28
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 23
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885 20
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 19
BCL2L1 Q07817 BCL2 like 1 Signaling 0.94 0.493 0.885 17
EDNRA P25101 endothelin receptor type A G-protein coupled receptor 0.99 0.426 0.885 17
GRK2 P25098 G protein-coupled receptor kinase 2 Kinase 1.00 0.532 0.654 15
CFL1 P23528 cofilin 1 0.56 0.529 0.769 14
PDE5A O76074 phosphodiesterase 5A 1.1E-04 0.513 0.731 14
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 12
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 11