Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1193 57
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 1157 8
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1119 24
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1101 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1083 13
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 1044 15
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
MIR21 microRNA 21 0.363 0.846 726 2
FN1 P02751 fibronectin 1 Signaling 1.4E-03 0.365 0.962 724 33
MTCO2P12 MT-CO2 pseudogene 12 0.368 0.962 703 0
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 671 22
CXCL10 P02778 C-X-C motif chemokine ligand 10 Signaling 0.37 0.378 0.885 631 9
CCN2 P29279 cellular communication network factor 2 Signaling 5.0E-04 0.399 0.846 518 2
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 514 6
PDGFRB P09619 platelet derived growth factor receptor beta Kinase 0.90 0.416 0.846 492 30
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846 485 114
RELA Q04206 RELA proto-oncogene, NF-kB subunit Transcription factor 1.00 0.406 0.885 483 11
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 460 26
SYT1 P21579 synaptotagmin 1 Transporter 0.60 0.412 0.846 460 15