Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
LMNA P02545 lamin A/C 1.00 0.384 0.885 824 285
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 805 74
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
FOXP3 Q9BZS1 forkhead box P3 0.99 0.368 0.846 688 27
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 687 76
CAV1 Q03135 caveolin 1 Enzyme modulator 8.3E-03 0.388 0.885 633 29
PTCH1 Q13635 patched 1 1.00 0.398 0.885 604 194
TWIST1 Q15672 twist family bHLH transcription factor 1 Transcription factor 0.34 0.397 0.846 559 31
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 551 52
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885 536 61
VWF P04275 von Willebrand factor Enzyme modulator 3.2E-25 0.408 0.885 498 158
F2 P00734 coagulation factor II, thrombin Enzyme 1.1E-03 0.415 0.885 490 42
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846 462 173
SMARCB1 Q12824 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Nucleic acid binding 1.00 0.434 0.846 448 30
TNFRSF11B O00300 TNF receptor superfamily member 11b 0.16 0.422 0.808 443 30
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 438 123
TRPV4 Q9HBA0 transient receptor potential cation channel subfamily V member 4 Ion channel 2.2E-16 0.457 0.808 422 56
COX1 P00395 cytochrome c oxidase subunit I Enzyme 0.441 0.885 421 89
GLI3 P10071 GLI family zinc finger 3 1.00 0.436 0.846 400 73
VCP P55072 valosin containing protein 1.00 0.469 0.923 376 25
TTN Q8WZ42 titin Kinase 2.6E-96 0.470 0.885 366 651
WWOX Q9NZC7 WW domain containing oxidoreductase Enzyme 1.2E-15 0.453 0.808 356 58