Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7528
Gene Symbol: YY1
YY1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy. 15567155

2005

Entrez Id: 7436
Gene Symbol: VLDLR
VLDLR
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart. 8603509

1996

Entrez Id: 54795
Gene Symbol: TRPM4
TRPM4
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats. 16966582

2006

Entrez Id: 9868
Gene Symbol: TOMM70
TOMM70
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. 25022898

2014

Entrez Id: 7079
Gene Symbol: TIMP4
TIMP4
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure. 10067796

1999

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Differential expression of cytokines in the rat heart in response to sustained volume overload. 15542404

2004

Entrez Id: 6770
Gene Symbol: STAR
STAR
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure. 19349910

2009

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Decreased Ca2+ extrusion via Na+/Ca2+ exchange in epicardial left ventricular myocytes during compensated hypertrophy. 15615841

2005

Entrez Id: 291
Gene Symbol: SLC25A4
SLC25A4
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Therapeutic RGD Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease. 17210842

2007

Entrez Id: 51548
Gene Symbol: SIRT6
SIRT6
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Biomarker RGD Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity. 22335191

2013

Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Therapeutic RGD Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. 25281201

2014

Entrez Id: 1901
Gene Symbol: S1PR1
S1PR1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. 11549339

2001

Entrez Id: 6271
Gene Symbol: S100A1
S100A1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart. 12619862

2003

Entrez Id: 6198
Gene Symbol: RPS6KB1
RPS6KB1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Disparate regulation of signaling proteins after exercise and myocardial infarction. 16540832

2006

Entrez Id: 387
Gene Symbol: RHOA
RHOA
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway. 17184496

2006

Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. 15728586

2005

Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Therapeutic RGD Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. 15749748

2005

Entrez Id: 1827
Gene Symbol: RCAN1
RCAN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.210 Biomarker RGD Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. 12124198

2002

Entrez Id: 10411
Gene Symbol: RAPGEF3
RAPGEF3
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy. 18323524

2008

Entrez Id: 10266
Gene Symbol: RAMP2
RAMP2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy. 15680493

2005

Entrez Id: 5837
Gene Symbol: PYGM
PYGM
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. 14618266

2003

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD [PTEN negatively regulates isoproterenol-induced cardiac hypertrophy and effects of captopril on PTEN expression]. 16188065

2005

Entrez Id: 5581
Gene Symbol: PRKCE
PRKCE
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. 15792354

2005

Entrez Id: 5580
Gene Symbol: PRKCD
PRKCD
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. 15792354

2005

Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Biomarker RGD Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats. 12887134

2003