Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart. 12494268

2003

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.220 Therapeutic RGD Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. 24342267

2014

Entrez Id: 10965
Gene Symbol: ACOT2
ACOT2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. 15292030

2004

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Biomarker RGD Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts. 21367774

2011

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Biomarker RGD Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. 24342267

2014

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.230 Biomarker RGD Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts. 21367774

2011

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.230 Biomarker RGD [Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy]. 11324571

1998

Entrez Id: 57085
Gene Symbol: AGTRAP
AGTRAP
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Effect of olmesartan on tissue expression balance between angiotensin II receptor and its inhibitory binding molecule. 18725581

2008

Entrez Id: 27063
Gene Symbol: ANKRD1
ANKRD1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter. 10904011

2000

Entrez Id: 302
Gene Symbol: ANXA2
ANXA2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Pressure overload induces overexpression of annexins II and V in aortic-banded rats. 10603972

1998

Entrez Id: 308
Gene Symbol: ANXA5
ANXA5
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Pressure overload induces overexpression of annexins II and V in aortic-banded rats. 10603972

1998

Entrez Id: 8862
Gene Symbol: APLN
APLN
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. 16674982

2006

Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Therapeutic RGD Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. 24998254

2014

Entrez Id: 9474
Gene Symbol: ATG5
ATG5
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Therapeutic RGD Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. 24998254

2014

Entrez Id: 477
Gene Symbol: ATP1A2
ATP1A2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Down-regulation of Na+ pump alpha 2 isoform in isoprenaline-induced cardiac hypertrophy in rat: evidence for increased receptor binding affinity but reduced inotropic potency of digoxin. 15644428

2005

Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Therapeutic RGD Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats. 29792884

2018

Entrez Id: 513
Gene Symbol: ATP5F1D
ATP5F1D
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Therapeutic RGD Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis. 25880160

2015

Entrez Id: 552
Gene Symbol: AVPR1A
AVPR1A
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Effects of novel vasopressin receptor antagonists on renal function and cardiac hypertrophy in rats with experimental congestive heart failure. 18467593

2008

Entrez Id: 572
Gene Symbol: BAD
BAD
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Therapeutic RGD Exercise training improves systolic function in hypertensive myocardium. 21921241

2011

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Therapeutic RGD Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. 24998254

2014

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. 23326547

2013

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Biomarker RGD Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy. 17487232

2006

Entrez Id: 952
Gene Symbol: CD38
CD38
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy. 18719074

2009

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. 18196276

2008

Entrez Id: 10699
Gene Symbol: CORIN
CORIN
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.210 Biomarker RGD Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. 15191894

2004