Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3976
Gene Symbol: LIF
LIF
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD "TGFbeta1 stimulates the over-production of white matter astrocytes from precursors of the ""brain marrow"" in a rodent model of neonatal encephalopathy." 20221422

2010

Entrez Id: 831
Gene Symbol: CAST
CAST
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD 3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydro-chloride 3.5 hydrate (DY-9760e) is neuroprotective in rat microsphere embolism: role of the cross-talk between calpain and caspase-3 through calpastatin. 16467455

2006

Entrez Id: 7432
Gene Symbol: VIP
VIP
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD VIP injection can reduce the infarct volume in rats with focal cerebral ischemia, suggesting the neuroprotective effect of VIP in brain ischemia possibly by reducing S100beta overexpression. 18158987

2007

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD NCX1 and NCX3: two new effectors of delayed preconditioning in brain ischemia. 22036625

2012

Entrez Id: 598
Gene Symbol: BCL2L1
BCL2L1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD A high soy diet reduces programmed cell death and enhances bcl-xL expression in experimental stroke. 17706879

2007

Entrez Id: 5058
Gene Symbol: PAK1
PAK1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion. 17997827

2007

Entrez Id: 6364
Gene Symbol: CCL20
CCL20
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation. 9916893

1998

Entrez Id: 2746
Gene Symbol: GLUD1
GLUD1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Accumulation of ammonia and changes in the activity of some ammonia metabolizing enzymes during brain ischemia/reperfusion injury in rats. 7808037

1995

Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat. 12598725

2003

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia. 15854740

2005

Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Acute-phase proteins before cerebral ischemia in stroke-prone rats: identification by proteomics. 11239198

2001

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Alterations in the expression of lipid and mechano-gated two-pore domain potassium channel genes in rat brain following chronic cerebral ischemia. 14741413

2004

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD Altered expression of sodium transporters in ischemic penumbra after focal cerebral ischemia in rats. 17662498

2007

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD Altered gene expression of Na+/Ca2+ exchanger isoforms NCX1, NCX2 and NCX3 in chronic ischemic rat brain. 12377375

2002

Entrez Id: 1356
Gene Symbol: CP
CP
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD An inhibition of ceruloplasmin expression induced by cerebral ischemia in the cortex and hippocampus of rats. 18273071

2008

Entrez Id: 4323
Gene Symbol: MMP14
MMP14
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. 15963646

2005

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. 15963646

2005

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Biomarker RGD Antioxidant activities of Dracocephalum tanguticum maxim extract and its up-regulation on the expression of neurotrophic factors in a rat model of permanent focal cerebral ischemia. 21213399

2011

Entrez Id: 2030
Gene Symbol: SLC29A1
SLC29A1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Astrocytes and neurons: different roles in regulating adenosine levels. 15829178

2005

Entrez Id: 3791
Gene Symbol: KDR
KDR
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Attenuation of edema and infarct volume following focal cerebral ischemia by early but not delayed administration of a novel small molecule KDR kinase inhibitor. 18951929

2009

Entrez Id: 839
Gene Symbol: CASP6
CASP6
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Caspase mRNA expression in a rat model of focal cerebral ischemia. 11311984

2001

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. 14502288

2003

Entrez Id: 2185
Gene Symbol: PTK2B
PTK2B
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. 10964954

2000

Entrez Id: 1234
Gene Symbol: CCR5
CCR5
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Cloning of rat HIV-1-chemokine coreceptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain. 9670989

1998

Entrez Id: 1439
Gene Symbol: CSF2RB
CSF2RB
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Cloning of rat interleukin-3 receptor beta-subunit from cultured microglia and its mRNA expression in vivo. 7643220

1995