Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.300 Biomarker RGD Portal hypertension and ascites in acute hepatitis: clinical, hemodynamic and histological correlations. 2777210

1989

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.230 Therapeutic RGD Tumor necrosis factor alpha: a major contributor to the hyperdynamic circulation in prehepatic portal-hypertensive rats. 7875478

1995

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.230 Biomarker RGD Hyperdynamic circulation in prehepatic portal hypertension: role of tumor necrosis factor-alpha. 9198288

1997

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.230 Therapeutic RGD Tumor necrosis factor alpha regulates nitric oxide synthase expression in portal hypertensive gastric mucosa of rats. 9537427

1998

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.230 Biomarker RGD Tumor necrosis factor-alpha regulates inducible nitric oxide synthase gene expression in the portal hypertensive gastric mucosa of the rat. 9834372

2006

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.230 Therapeutic RGD Factors mediating the hemodynamic effects of tumor necrosis factor-alpha in portal hypertensive rats. 10070045

1999

Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD A tungsten supplemented diet attenuates bacterial translocation in chronic portal hypertensive and cholestatic rats: role of xanthine dehydrogenase and xanthine oxidase. 10562591

1999

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.210 Therapeutic RGD Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. 10727442

2000

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.510 Biomarker RGD Role of aortic nitric oxide synthase 3 (eNOS) in the systemic vasodilation of portal hypertension. 10889169

2000

Entrez Id: 1843
Gene Symbol: DUSP1
DUSP1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa: relevance of MKP-1, c-fos, c-myc, and cyclin D1 expression. 11758828

2001

Entrez Id: 5295
Gene Symbol: PIK3R1
PIK3R1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.210 Biomarker RGD Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway. 11826414

2002

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes. 11832453

2002

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing? 14525948

2003

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Tumor necrosis factor-alpha, interleukin-1beta and nitric oxide: induction of liver megamitochondria in prehepatic portal hypertensive rats. 15951934

2005

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.510 Biomarker RGD A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. 16142243

2005

Entrez Id: 156
Gene Symbol: GRK2
GRK2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. 16142243

2005

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.230 Biomarker RGD Antioxidant role of heme oxygenase-1 in prehepatic portal hypertensive rats. 16830363

2006

Entrez Id: 5617
Gene Symbol: PRL
PRL
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Role of ammonia and nitric oxide in the decrease in plasma prolactin levels in prehepatic portal hypertensive male rats. 17119344

2006

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.210 Biomarker RGD [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. 17214938

2007

Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. 17214938

2007

Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. 17214938

2007

Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats. 17351970

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. 17876871

2007

Entrez Id: 1644
Gene Symbol: DDC
DDC
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. 18457899

2008

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.500 Biomarker RGD Restriction of drinking water abrogates splanchnic vasodilation and portal hypertension in portal vein-ligated rats. 18987488

2009