Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0028754
Disease: Obesity
Obesity 		0.240 Biomarker RGD RANTES and MCP-1 serum levels were increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with rimonabant, which slowed weight gain in rats with the metabolic syndrome. 18469848

2008
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0006272
Disease: Bronchiolitis Obliterans
Bronchiolitis Obliterans 		0.200 Biomarker RGD A model of chronic lung allograft rejection in the rat. 19840961

2010
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0243026
Disease: Sepsis
Sepsis 		0.200 Biomarker RGD Activated protein C modulates chemokine response and tissue injury in experimental sepsis. 18290317

2008
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C1332309
Disease: Anti-Basement Membrane Glomerulonephritis
Anti-Basement Membrane Glomerulonephritis 		0.200 Biomarker RGD Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. 17898087

2008
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0014869
Disease: Peptic Esophagitis
Peptic Esophagitis 		0.200 Biomarker RGD Although the oesophagitis lesion index in the RO+BA group did not differ from that in the RO group, eosinophilic infiltration in the oesophageal submucosa and levels of mRNA expression of cytokines such as IL5, IL10, IL13, and RANTES were significantly increased. 18222984

2008
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.210 Biomarker RGD Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis. 16843865

2006
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0006272
Disease: Bronchiolitis Obliterans
Bronchiolitis Obliterans 		0.200 Biomarker RGD Both MCP-1 and RANTES are functional in the formation of the fibroproliferative response that characterizes OB in this model, and their antagonization conferred protection against airway obstruction and epithelial loss. 14611812

2003
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.240 Biomarker RGD CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair. 18954648

2008
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0030193
Disease: Pain
Pain 		0.220 Biomarker RGD Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. 11438578

2001
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.280 Biomarker RGD Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. 18595729

2008
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.220 Biomarker RGD Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. 18076762

2007
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut. 15542513

2004
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.290 Biomarker RGD Dietary fatty acid unsaturation levels, lipoprotein oxidation and circulating chemokine in experimentally induced atherosclerotic rats. 16259780

2005
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.220 Biomarker RGD DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. 15882261

2005
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy 		0.200 Biomarker RGD Human amniotic fluid mesenchymal stem cells in combination with hyperbaric oxygen augment peripheral nerve regeneration. 19152028

2009
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0032914
Disease: Pre-Eclampsia
Pre-Eclampsia 		0.200 Biomarker RGD Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension. 19617880

2009
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.210 Biomarker RGD Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome. 19905967

2009
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0021368
Disease: Inflammation
Inflammation 		0.220 Biomarker RGD In our study, we established the involvement of RANTES in an in vivo model of chronic inflammation induced by potassium permanganate, leading to calcified granulomas. 17164972

2007
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.200 Biomarker RGD Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat. 16215387

2005
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0009766
Disease: Allergic Conjunctivitis
Allergic Conjunctivitis 		0.200 Biomarker RGD Mast-cell activation augments the late phase reaction in experimental immune-mediated blepharoconjunctivitis. 12682842

2003
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0018790
Disease: Cardiac Arrest
Cardiac Arrest 		0.210 Biomarker RGD Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. 19756023

2010
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0600228
Disease: Cardiopulmonary Arrest
Cardiopulmonary Arrest 		0.200 Biomarker RGD Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. 19756023

2010
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0020500
Disease: Hyperoxaluria
Hyperoxaluria 		0.500 Biomarker RGD NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system. 16284884

2005
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0001306
Disease: Acute alcoholic liver disease
Acute alcoholic liver disease 		0.200 Therapeutic RGD Optimal ratio of 18α- and 18β-glycyrrhizic acid for preventing alcoholic hepatitis in rats. 31258651

2019
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.220 Biomarker RGD Pretreatment with antibodies against RANTES/CCL5 prevented the hyperalgesic response, indicating that RANTES/CCL5 is able to interfere with the control of hyperalgesia at the level of the periaqueductal grey and suggesting that chemokine blockers could have analgesic properties. 18656466

2008