×
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer.
25058500 2015
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer.
25058500 2015
×
Entrez Id: 7518
Gene Symbol: XRCC4
XRCC4
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer.
25058500 2015
×
Entrez Id: 9156
Gene Symbol: EXO1
EXO1
Hereditary Nonpolyposis Colorectal Neoplasms
0.310
Biomarker
CLINGEN
Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients.
24484585 2014
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.
24976383 2014
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
25368522 2014
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas.
24512911 2014
×
Entrez Id: 64218
Gene Symbol: SEMA4A
SEMA4A
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.
25307848 2014
×
Entrez Id: 6224
Gene Symbol: RPS20
RPS20
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Germline mutation of RPS20, encoding a ribosomal protein, causes predisposition to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency.
24941021 2014
×
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Hereditary Nonpolyposis Colorectal Neoplasms
0.900
Biomarker
CLINGEN
Cancer risks for MLH1 and MSH2 mutation carriers.
23255516 2013
×
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues.
23228367 2013
×
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
The Genotype-Tissue Expression (GTEx) project.
23715323 2013
×
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer.
22494821 2012
×
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome.
22814582 2012
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.
23154512 2012
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.
21807500 2011
×
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Association of low-risk MSH3 and MSH2 variant alleles with Lynch syndrome: probability of synergistic effects.
21128252 2011
×
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.
20624957 2010
×
Entrez Id: 22909
Gene Symbol: FAN1
FAN1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
20603016 2010
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
CHEK2 mutations and HNPCC-related colorectal cancer.
19876921 2010
×
Entrez Id: 22909
Gene Symbol: FAN1
FAN1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
20603073 2010
×
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
Hereditary Nonpolyposis Colorectal Neoplasms
0.500
Biomarker
CLINGEN
Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome.
19156873 2009
×
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
Hereditary Nonpolyposis Colorectal Neoplasms
0.500
Biomarker
CLINGEN
Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.
19483466 2009
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.
18996005 2009
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.
18790734 2008