Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10699
Gene Symbol: CORIN
CORIN
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.210 Biomarker RGD Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. 15191894

2004
Entrez Id: 1827
Gene Symbol: RCAN1
RCAN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.210 Biomarker RGD Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. 12124198

2002
Entrez Id: 513
Gene Symbol: ATP5F1D
ATP5F1D
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis. 25880160

2015
Entrez Id: 3297
Gene Symbol: HSF1
HSF1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD HSF1 and NF-κB p65 participate in the process of exercise preconditioning attenuating pressure overload-induced pathological cardiac hypertrophy. 25804640

2015
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. 24998254

2014
Entrez Id: 9868
Gene Symbol: TOMM70
TOMM70
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. 25022898

2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. 25281201

2014
Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Hepcidin is increased in the hypertrophied heart of Dahl salt-sensitive rats. 24424338

2014
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. 24998254

2014
Entrez Id: 9474
Gene Symbol: ATG5
ATG5
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. 24998254

2014
Entrez Id: 10038
Gene Symbol: PARP2
PARP2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. 25281201

2014
Entrez Id: 84557
Gene Symbol: MAP1LC3A
MAP1LC3A
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. 24998254

2014
Entrez Id: 4976
Gene Symbol: OPA1
OPA1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. 24388463

2014
Entrez Id: 4722
Gene Symbol: NDUFS3
NDUFS3
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. 24388463

2014
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300. 23211718

2013
Entrez Id: 407030
Gene Symbol: MIR30B
MIR30B
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. 23326547

2013
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. 23326547

2013
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy. 22000973

2013
Entrez Id: 55869
Gene Symbol: HDAC8
HDAC8
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activity. 23868068

2013
Entrez Id: 407029
Gene Symbol: MIR30A
MIR30A
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. 23326547

2013
Entrez Id: 8473
Gene Symbol: OGT
OGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure. 22128088

2012
Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD The protective role of peroxisome proliferator-activated receptor γ coactivator-1α in hyperthyroid cardiac hypertrophy. 22105890

2012
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats. 22160250

2012
Entrez Id: 572
Gene Symbol: BAD
BAD
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Exercise training improves systolic function in hypertensive myocardium. 21921241

2011
Entrez Id: 157
Gene Symbol: GRK3
GRK3
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Gender differences in β-adrenoceptor system in cardiac hypertrophy due to arteriovenous fistula. 20677219

2011