Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.210 Biomarker RGD Isorhapontigenin, a new resveratrol analog, attenuates cardiac hypertrophy via blocking signaling transduction pathways. 15607907

2005
Entrez Id: 10699
Gene Symbol: CORIN
CORIN
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.210 Biomarker RGD Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. 15191894

2004
Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. 15728586

2005
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. 24998254

2014
Entrez Id: 477
Gene Symbol: ATP1A2
ATP1A2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Down-regulation of Na+ pump alpha 2 isoform in isoprenaline-induced cardiac hypertrophy in rat: evidence for increased receptor binding affinity but reduced inotropic potency of digoxin. 15644428

2005
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300. 23211718

2013
Entrez Id: 9868
Gene Symbol: TOMM70
TOMM70
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. 25022898

2014
Entrez Id: 407030
Gene Symbol: MIR30B
MIR30B
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. 23326547

2013
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. 23326547

2013
Entrez Id: 291
Gene Symbol: SLC25A4
SLC25A4
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease. 17210842

2007
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. 25281201

2014
Entrez Id: 572
Gene Symbol: BAD
BAD
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Therapeutic RGD Exercise training improves systolic function in hypertensive myocardium. 21921241

2011
Entrez Id: 5837
Gene Symbol: PYGM
PYGM
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. 14618266

2003
Entrez Id: 8862
Gene Symbol: APLN
APLN
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. 16674982

2006
Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Hepcidin is increased in the hypertrophied heart of Dahl salt-sensitive rats. 24424338

2014
Entrez Id: 157
Gene Symbol: GRK3
GRK3
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Gender differences in β-adrenoceptor system in cardiac hypertrophy due to arteriovenous fistula. 20677219

2011
Entrez Id: 1901
Gene Symbol: S1PR1
S1PR1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. 11549339

2001
Entrez Id: 10411
Gene Symbol: RAPGEF3
RAPGEF3
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy. 18323524

2008
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD 17beta-estradiol regulates constitutive nitric oxide synthase expression differentially in the myocardium in response to pressure overload. 17673519

2007
Entrez Id: 3037
Gene Symbol: HAS2
HAS2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. 18196276

2008
Entrez Id: 8473
Gene Symbol: OGT
OGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure. 22128088

2012
Entrez Id: 4624
Gene Symbol: MYH6
MYH6
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism. 1703406

1991
Entrez Id: 5581
Gene Symbol: PRKCE
PRKCE
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. 15792354

2005
Entrez Id: 302
Gene Symbol: ANXA2
ANXA2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Pressure overload induces overexpression of annexins II and V in aortic-banded rats. 10603972

1998
Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD The protective role of peroxisome proliferator-activated receptor γ coactivator-1α in hyperthyroid cardiac hypertrophy. 22105890

2012