×
Entrez Id: 836
Gene Symbol: CASP3
CASP3
Diabetes Mellitus, Insulin-Dependent
0.290
Biomarker
RGD
The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats.
15855338 2005
×
Entrez Id: 2688
Gene Symbol: GH1
GH1
Diabetes Mellitus, Insulin-Dependent
0.290
Biomarker
RGD
Growth hormone responsiveness in vivo and in vitro to growth hormone releasing factor in the spontaneously diabetic BB Wistar rat.
2888037 1987
×
Entrez Id: 345
Gene Symbol: APOC3
APOC3
Diabetes Mellitus, Insulin-Dependent
0.270
Biomarker
RGD
Lowering apolipoprotein CIII delays onset of type 1 diabetes.
21670290 2011
×
Entrez Id: 3651
Gene Symbol: PDX1
PDX1
Diabetes Mellitus, Insulin-Dependent
0.260
Biomarker
MGD
×
Entrez Id: 868
Gene Symbol: CBLB
CBLB
Diabetes Mellitus, Insulin-Dependent
0.250
SusceptibilityMutation
RGD
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
12118252 2002
×
Entrez Id: 55340
Gene Symbol: GIMAP5
GIMAP5
Diabetes Mellitus, Insulin-Dependent
0.250
Biomarker
RGD
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
12097339 2002
×
Entrez Id: 55340
Gene Symbol: GIMAP5
GIMAP5
Diabetes Mellitus, Insulin-Dependent
0.250
Biomarker
RGD
The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.
12031988 2002
×
Entrez Id: 868
Gene Symbol: CBLB
CBLB
Diabetes Mellitus, Insulin-Dependent
0.250
Biomarker
RGD
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
12118252 2002
×
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
Diabetes Mellitus, Insulin-Dependent
0.250
Biomarker
MGD
×
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
Diabetes Mellitus, Insulin-Dependent
0.240
Biomarker
RGD
In summary, combined proteome-transcriptome-genome and functional analyses identify gal-3 as a candidate gene/protein in T1D susceptibility that may prove valuable in future intervention/prevention strategies.
16600178 2006
×
Entrez Id: 3554
Gene Symbol: IL1R1
IL1R1
Diabetes Mellitus, Insulin-Dependent
0.240
Biomarker
MGD
IL-1 receptor deficiency slows progression to diabetes in the NOD mouse.
14693705 2004
×
Entrez Id: 199
Gene Symbol: AIF1
AIF1
Diabetes Mellitus, Insulin-Dependent
0.240
ModifyingMutation
RGD
Identification, isolation, and characterization of daintain (allograft inflammatory factor 1), a macrophage polypeptide with effects on insulin secretion and abundantly present in the pancreas of prediabetic BB rats.
9391121 1997
×
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
Diabetes Mellitus, Insulin-Dependent
0.230
Biomarker
RGD
Costimulation and autoimmune diabetes in BB rats.
16611325 2006
×
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
Diabetes Mellitus, Insulin-Dependent
0.230
Therapeutic
RGD
Prevention of autoimmune diabetes in the DRBB rat by CD40/154 blockade.
12419284 2002
×
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
RGD
Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes.
23111281 2013
×
Entrez Id: 356
Gene Symbol: FASLG
FASLG
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
RGD
A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model.
17324464 2007
×
Entrez Id: 952
Gene Symbol: CD38
CD38
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
MGD
Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
16585549 2006
×
Entrez Id: 6402
Gene Symbol: SELL
SELL
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
MGD
Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors.
14662758 2004
×
Entrez Id: 7450
Gene Symbol: VWF
VWF
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
RGD
Aortic endothelial cell von Willebrand factor content, and circulating plasminogen activator inhibitor-1 are increased, but expression of endothelial leukocyte adhesion molecules is unchanged in insulin-dependent diabetic BB rats.
10729383 2000
×
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
MGD
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia.
10319860 1999
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
RGD
Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats.
2833110 1988
×
Entrez Id: 356
Gene Symbol: FASLG
FASLG
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
MGD
×
Entrez Id: 81704
Gene Symbol: DOCK8
DOCK8
Diabetes Mellitus, Insulin-Dependent
0.210
Biomarker
RGD
A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes .
26363782 2015
×
Entrez Id: 6356
Gene Symbol: CCL11
CCL11
Diabetes Mellitus, Insulin-Dependent
0.210
Biomarker
RGD
Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model.
23049540 2012
×
Entrez Id: 51083
Gene Symbol: GAL
GAL
Diabetes Mellitus, Insulin-Dependent
0.210
Biomarker
RGD
We conclude that the selective damage to islet sympathetic nerve terminals seen in BB diabetic rats, rather than the systemic factors of diabetic hyperglycemia or insulin deficiency, causes the increased galanin expression observed in the CG of this animal model of type 1 diabetes .
16487586 2006