Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD (3) There was a significant positive correlation between the percentage of cells with p-ERK in peripheral blood lymphocytes and IL-13 protein in supernatants of lymphocytes from asthmatic rats. 20819635

2010

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD (2) IL-13 protein in supernatants of asthmatic lymphocytes was higher than that produced by normal control lymphocytes, and was significantly increased by EGF treatment. 20819635

2010

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD In this study, we intend to explore the role of ERK in the expression of the Th2 cytokine, interleukin 13 (IL-13) in lymphocytes in asthma. 20819635

2010

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD In asthma the ERK expression and activation levels were increased, as was the protein level of IL-13. 20819635

2010

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD Role of extracellular signal-regulated kinase in regulating expression of interleukin 13 in lymphocytes from an asthmatic rat model. 20819635

2010

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD The ERK signaling pathway may be involved in the increased expression of the Th2 cytokine IL-13 in asthma. 20819635

2010

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD Significant increases in the number of cells, especially eosinophils, and IL13 but not IFN-gamma concentration in BALF were observed in the RO+BA group compared with the BA group. 18222984

2008

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD Although the oesophagitis lesion index in the RO+BA group did not differ from that in the RO group, eosinophilic infiltration in the oesophageal submucosa and levels of mRNA expression of cytokines such as IL5, IL10, IL13, and RANTES were significantly increased. 18222984

2008

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation. 12604708

2003

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma
0.600 Therapeutic RGD After the treatment, changes of EOS in peripheral blood of asthma rats were observed; enzyme linked immunosorbent assay (ELISA) was applied to test the contents of IgE, IL-4 and IFN-gamma in the lung tissue; real-time Q-PCR method was adopted to measure the expression level of transcription factor T-bet and GATA binding protein 3 (GATA-3) in the lung tissue. 24946644

2014

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Therapeutic RGD The inflammatory cells and the percentage of EOS in BALF, IL-5 levels in BALF and IL-5 mRNA expression in the lung tissues were obviously higher in the untreated asthma group than the control group (P<0.05), while the parameters in the IPD or BUD-treated asthma groups were significantly lower than the untreated asthma group (P<0.05). 25008888

2014

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Therapeutic RGD IPD treatment can alleviate airway inflammation in asthmatic rats, possibly through inhibiting IL-5 mRNA transcripts. 25008888

2014

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Therapeutic RGD To study the effects of suplatast tosilate (IPD) on the airway inflammation and expression of interleukin-5 in asthmatic rats. 25008888

2014

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Therapeutic RGD [Effects of suplatast tosilate on airway inflammation and interleukin-5 in asthmatic rats]. 25008888

2014

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.600 Therapeutic RGD Zinc suppressed the airway inflammation in asthmatic rats: effects of zinc on generation of eotaxin, MCP-1, IL-8, IL-4, and IFN-γ. 22932891

2013

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Phosphatidylinositol 3-kinase inhibitor suppresses inducible nitric oxide synthase expression in bronchiole epithelial cells in asthmatic rats. 21847581

2012

Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. 20953388

2011

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs. 21364926

2011

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD This study explored a new approach to asthma therapy in which allergic rats were transfected with the IL-5 antisense gene delivered by the recombinant adeno-associated virus (rAAV-ASIL-5). 19947994

2010

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD 20 +/- 1.75)%] were all significantly higher than those of the control group [(1.51 +/- 1.04) x 10(7)/L, (0.70 +/- 0.48)%] (P < 0.01); the total cell numbers in BALF, the absolute numbers of EOS and EOS% of RA groups [(14.89 +/- 2.35) x 10(7)/L, (4.70 +/- 0.82)%; (10.98 +/- 1.81) x 10(7)/L, (3.56 +/- 0.53)%] were all significantly lower than those of asthma group (P < 0.01); (2) The concentration of IL-4 in BALF of asthma group (25.70 +/- 7.36) was significantly higher than that of the control group (8.55 +/- 2.97) (P < 0.01); the concentration of IL-4 of BALF of RA groups [(31.89 +/- 5.46), (35.26 +/- 6.03)] was significantly lower than that of asthma group (P < 0.01); the concentration of IL-12 of BALF of asthma group (16.10 +/- 3.38) was significantly lower than that of the control group (42.33 +/- 9.66) (P < 0.01); the concentration of IL-12 of BALF of the RA groups [(31.89 +/- 5.46), (35.26 +/- 6.03)] was significantly higher than that of the asthma group (P < 0.01); (3) Immunohistochemistry and in situ hybridization showed that the protein content of STAT4 and the STAT4 mRNA expression around the bronchus of asthma group [(0.096 +/- 0.012), (0.098 +/- 0.011)] were lower than those of the control group [(0.216 +/- 0.034), (0.228 +/- 0.032)], while those of RA groups [(0.176 +/- 0.012), (0.185 +/- 0.023); (0.183 +/- 0.011), (0.201 +/- 0.019)] were all significantly higher than that of the asthma group (P < 0.01), the airway smooth muscle cells, the pulmonary arterial smooth muscle cells and endothelial cells were the chief expression cells; (4) the STAT4 and the STAT4mRNA expression around the bronchus had positive correlation with the concentration of IL-12 in BALF while had negative correlation with the concentration of IL-4, absolute numbers of EOS in BALF. 18211752

2010

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma. 18208670

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD [The effect of cigarette smoke on the expression of transforming growth factor-beta1 mRNA and collagen type III in airways of asthmatic rats]. 18366906

2008

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Galectin-3, a selective inhibitor of IL-5 mRNA transcription, potentially suppresses eosinophilic inflammation and might be a promising specific anti-asthma agent. 17074272

2006

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models]. 17074272

2006

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models]. 17074272

2006