×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
UNIPROT
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
Biomarker
HPO
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
CausalMutation
CGI
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
E-cadherin gene mutations have previously been detected in advanced diffuse-type gastric cancer and gastric carcinoma cell lines.8973475 1996
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
Biomarker
CTD_human
E-cadherin germline mutations in familial gastric cancer.
9537325 1998
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
Biomarker
CTD_human
However, only a minority of familial gastric cancers can be accounted for by CDH1 mutations.
10072428 1999
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
Familial gastric cancer is genetically heterogeneous and it is not clear what proportion of gastric cancer susceptibility in non-Maori populations is due to germline CDH1 mutations.
10072428 1999
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
PosttranslationalModification
BEFREE
The E-cadherin promoter frequently undergoes hypermethylation in human gastric cancers , particularly those of the undifferentiated-scattered histologic subtype.
10749913 2000
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer .
11598162 2001
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
No truncating or splice site CDH1 mutations were identified by PCR single-strand conformational polymorphism in these families or in eight individual patients who had both prostate and gastric cancer .
11705864 2001
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin ) mutation carriers from hereditary diffuse gastric cancer families.
11729114 2001
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer .12216071 2002
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer .12209998 2002
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
Biomarker
BEFREE
Cell adhesion molecule abnormalities such as those involving CDH1 may play an important role in diffuse-type gastric cancer development.
11979414 2002
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
Heterozygotes with the CDH1 mutation have a 70-80% chance of developing gastric cancer and once patients have invasive, symptomatic disease there is a high associated morbidity and mortality.
12145417 2002
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer .
12444556 2002
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
Here we report the results of germline CDH1 mutation screening in 39 kindred with familial aggregation of gastric cancer , a subset of which fulfills the criteria defined by the IGCLC for HDGC.
11968083 2002
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
The mutation to the E-cadherin gene has high penetrance and confers a lifetime risk of gastric cancer of 80% for carriers.
11998610 2002
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
We screened all exons of the E-cadherin gene for mutations in 101 Japanese patients having an intense family history of gastric cancers .
12604719 2003
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
Biomarker
CTD_human
We screened a series of 66 young gastric cancer probands for germline CDH1 mutations, and two novel missense alterations together with an intronic variant were identified.
12588804 2003
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer .
12923325 2003
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
The novel CDH1 nucleotide change is uncommon in Italian patients with sporadic diffuse gastric cancer .
14610318 2003
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
The role of the E-cadherin gene (CDH1 ) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice.
14630673 2003
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
It is likely that unidentified mutations in CDH1 or other involved genes contribute to diffuse gastric cancer susceptibility.
12908778 2003
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Malignant neoplasm of stomach
0.800
GeneticVariation
BEFREE
Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset gastric cancer for CDH1 germline mutations.
15288293 2004