Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation UNIPROT

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 Biomarker HPO

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 CausalMutation CGI

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 Biomarker BEFREE 59 GCs, 59 first degree relatives (FDRs) of GC, 20 autoimmune metaplastic atrophic gastritis (AMAGs) and 52 blood donors (BDs) were analyzed for CDH1 by direct sequencing, structural modelling and bioinformatics. 24204729

2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE Gastric cancer (GC) is considered to be one of the leading cancers in East Asians, and mutations in the CDH1 gene and the reduced expression of E-cadherin are the most frequent genetic alterations in gastric cancer. 23435907

2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer. 12209998

2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. 12216071

2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE E-cadherin gene C-160A promoter polymorphism may not play a major role in the etiology of non-cardia gastric cancer in Chinese population. 15609397

2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 Biomarker BEFREE CDH1 associated gastric cancer: a report of a family and review of the literature. 15780560

2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 PosttranslationalModification BEFREE CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion. 16531765

2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 mutations in individuals from families with HDGC are associated with gastric cancer in a highly penetrant fashion. 17522512

2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 PosttranslationalModification BEFREE E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. 18249489

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE E-cadherin gene alterations in gastric cancers in different ethnic populations. 18646324

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 C-160A promoter polymorphism and gastric cancer risk. 19077564

2009
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). 20632448

2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 Biomarker BEFREE E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer. 21106365

2011
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 mutation carriers have a strongly increased risk of developing gastric cancer (GC) and lobular breast cancer (LBC). 22020549

2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 mutation testing in families with a history of gastric cancer and prophylactic gastrectomy in mutation-positive patients are recommended for the management of HDGC. 22160243

2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 PosttranslationalModification BEFREE CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer. 22514028

2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 somatic alterations were found in approximately 30% of all patients with GC. 23341533

2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer. 25981591

2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 AlteredExpression BEFREE CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with HOTAIR (r(2)=0.154, P=0.0354). 26136075

2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer. 30642281

2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 PosttranslationalModification BEFREE CDH1 hypermethylation status was found to be associated with advancement of disease, distant organ metastases and lymph node invasion in Gastric cancer patients. 30989488

2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.800 GeneticVariation BEFREE E-cadherin gene mutations have previously been detected in advanced diffuse-type gastric cancer and gastric carcinoma cell lines. 8973475

1996