Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight. 17517446

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight. 17517446

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.700 Biomarker CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672

1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. 9502777

1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672

1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672

1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. 9502777

1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Congenital leptin deficiency is associated with severe early-onset obesity in humans. 9202122

1997
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Congenital leptin deficiency is associated with severe early-onset obesity in humans. 9202122

1997
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Therapeutic CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540

1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Therapeutic CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540

1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. 27712037

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human Central Leptin and Tumor Necrosis Factor-α (TNFα) in Diurnal Control of Blood Pressure and Hypertension. 27226618

2016
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice. 24525044

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats. 25205467

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.600 Biomarker CTD_human Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. 24150608

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.600 Biomarker CTD_human Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344). 21315688

2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Therapeutic CTD_human Leptin, an adipocytokine involved in cell survival and in learning, has been demonstrated to regulate Abeta production and tau hyperphosphorylation in transgenic mice for AD. 20157255

2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. 19716478

2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker CTD_human Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia. 18515891

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human Serum leptin levels correlation with high blood pressure in adult females. 16827954

2006