×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Erectile dysfunction
0.600
Therapeutic
CTD_human
Altered growth factor expression in the aging penis: the Brown-Norway rat model.
12002441 2002
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Erectile dysfunction
0.600
Biomarker
CTD_human
Altered growth factor expression in the aging penis: the Brown-Norway rat model.
12002441 2002
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Myocardial Infarction
0.600
Biomarker
CTD_human
Homozygosity for a common NOS 3 polymorphism (894 G-->T) which encodes a Glu298-->Asp amino acid substitution in eNOS is a risk factor for angiographic CAD and recent MI in this population.
10510054 1999
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Essential Hypertension
0.600
Biomarker
CTD_human
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Hyperlipidemia
0.530
Biomarker
CTD_human
To study the role of eNOS in the control of the metabolic action of insulin, we assessed insulin sensitivity in conscious mice with disruption of the gene encoding for eNOS . eNOS (-/-) mice were hypertensive and had fasting hyperinsulinemia, hyperlipidemia , and a 40% lower insulin-stimulated glucose uptake than control mice.
11457755 2001
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetic Angiopathies
0.520
Biomarker
CTD_human
ecNOS gene polymorphism is associated with endothelium-dependent vasodilation in Type 2 diabetes.
12124201 2002
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Portal Hypertension
0.510
Therapeutic
CTD_human
Liposome-mediated gene transfer of endothelial nitric oxide synthase to cirrhotic rat liver decreases intrahepatic vascular resistance.
18070013 2008
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiomegaly
0.510
Biomarker
CTD_human
Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy.
17487232 2006
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiomegaly
0.510
Therapeutic
CTD_human
Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy.
17487232 2006
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiomegaly
0.510
Biomarker
CTD_human
Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure.
16844920 2006
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiomegaly
0.510
Therapeutic
CTD_human
Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure.
16844920 2006
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Pulmonary Edema
0.510
Therapeutic
CTD_human
In conclusion, low-dose simvastatin therapy significantly improves survival and cardiac function and reduces both cardiac hypertrophy and pulmonary edema via an eNOS -dependent mechanism in a murine model of CHF.
16844920 2006
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiomegaly
0.510
Biomarker
CTD_human
Overexpression of endothelial nitric oxide synthase attenuates cardiac hypertrophy induced by chronic isoproterenol infusion.
12224825 2002
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiomegaly
0.510
Therapeutic
CTD_human
Overexpression of endothelial nitric oxide synthase attenuates cardiac hypertrophy induced by chronic isoproterenol infusion.
12224825 2002
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiomegaly
0.510
Therapeutic
CTD_human
Adeno-associated virus-mediated transfer of endothelial nitric oxide synthase gene inhibits protein synthesis of rat ventricular cardiomyocytes.
11504159 2001
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiomegaly
0.510
Biomarker
CTD_human
Adeno-associated virus-mediated transfer of endothelial nitric oxide synthase gene inhibits protein synthesis of rat ventricular cardiomyocytes.
11504159 2001
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Experimental
0.500
Biomarker
CTD_human
Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment.
22191573 2012
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Experimental
0.500
Biomarker
CTD_human
Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice.
22933112 2012
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Pulmonary Hypertension
0.500
Biomarker
CTD_human
We studied the correlation between the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and pulmonary hypertension in children with congenital cardiac diseases.
21144100 2011
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Cardiovascular Diseases
0.500
Biomarker
CTD_human
Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.
20610621 2010
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Experimental
0.500
Biomarker
CTD_human
Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress.
19478208 2009
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Insulin Resistance
0.500
Biomarker
CTD_human
These data highlight the potential utility of eNOS gene therapy in the treatment of hypertension and insulin resistance .
19008412 2009
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Insulin Resistance
0.500
Therapeutic
CTD_human
These data highlight the potential utility of eNOS gene therapy in the treatment of hypertension and insulin resistance .
19008412 2009
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Gastric ulcer
0.500
Biomarker
CTD_human
Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice.
19066340 2009
×
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Coronary Artery Disease
0.500
Biomarker
CTD_human
This FSS-induced rise in SOD-2 expression in CC-genotype ECs effectively stabilizes their antiatherosclerotic phenotype and may explain not only the comparatively slow onset of CAD in homozygous carriers of the C-allele of the nos-3 gene but also define a general strategy for preventing endothelial dysfunction at the outset of atherosclerosis.
19696404 2009