|
rs2228570
|
|
Sporadic Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association with the minor allele A of the non-synonymous SNP rs2228570 (rs10735810, FokI, Met1Thr) was observed for BC, with an estimated odds ratio (OR) of 1.26 (95% CI = 1.02-1.57; p = 0.036).
|
19105801 |
2008 |
|
rs2228570
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Nevertheless, sub-group analyses revealed an association between rs2228570 (FokI) and absence of childhood sunburns (OR = 0.65, p = 0.003), between the 3'utr SNP rs739837 (BglI) and fair skin (OR = 1.31, p = 0.048), and between the promoter SNP rs4516035 and the more aggressive tumour location in head-neck and trunk (OR = 1.54, p = 0.020).
|
19105801 |
2008 |
|
rs2228570
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNP) in the VDR gene (VDR), rs1544410 (BsmI), and rs2228570 (FokI), have been inconsistently associated with breast cancer risk.
|
19124512 |
2009 |
|
rs2228570
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNP) in the VDR gene (VDR), rs1544410 (BsmI), and rs2228570 (FokI), have been inconsistently associated with breast cancer risk.
|
19124512 |
2009 |
|
rs2228570
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between FokI (rs2228570) and BsmI (rs1544410) of the vitamin D receptor (VDR) gene polymorphisms and patients with CAD in a Chinese population.
|
19563249 |
2009 |
|
rs2228570
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The most extensively studied SNPs including rs10735810, also known as rs2228570 (Fok1, VDR), rs1544410 (Bsm1, VDR), and rs2296241 (CYP24A1), were not associated with breast cancer risk.
|
21828234 |
2011 |
|
rs2228570
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
For example, breast cancer risk was associated with the GC rs7041 TT genotype (age-adjusted odds ratio (OR) = 1.23; 95% CI: 1.01, 1.51) and inversely with the VDR Fok1 (rs2228570) ff genotype (OR = 0.71; 95% CI: 0.57, 0.88).
|
21693626 |
2011 |
|
rs2228570
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
For example, breast cancer risk was associated with the GC rs7041 TT genotype (age-adjusted odds ratio (OR) = 1.23; 95% CI: 1.01, 1.51) and inversely with the VDR Fok1 (rs2228570) ff genotype (OR = 0.71; 95% CI: 0.57, 0.88).
|
21693626 |
2011 |
|
rs2228570
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The most extensively studied SNPs including rs10735810, also known as rs2228570 (Fok1, VDR), rs1544410 (Bsm1, VDR), and rs2296241 (CYP24A1), were not associated with breast cancer risk.
|
21828234 |
2011 |
|
rs2228570
|
|
Carcinoma, Ovarian Epithelial
|
|
0.050 |
GeneticVariation
|
BEFREE |
This pooled analysis provides further evidence that the VDR rs2228570 polymorphism might influence ovarian cancer susceptibility.
|
20473893 |
2011 |
|
rs2228570
|
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Within the asthma cohort, multiple significant associations between SNPs and asthma characteristics were identified; VDR SNP rs2228570 was associated with the higher nighttime asthma morbidity scores (P = 0.04), lower baseline spirometric measures (P < 0.05), 1 or more positive aeroallergen skin test (P = 0.003), and increased immunoglobulin E levels (P < 0.001).
|
21613960 |
2011 |
|
rs2228570
|
|
ovarian neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
This pooled analysis provides further evidence that the VDR rs2228570 polymorphism might influence ovarian cancer susceptibility.
|
20473893 |
2011 |
|
rs2228570
|
|
Malignant neoplasm of ovary
|
|
0.050 |
GeneticVariation
|
BEFREE |
This pooled analysis provides further evidence that the VDR rs2228570 polymorphism might influence ovarian cancer susceptibility.
|
20473893 |
2011 |
|
rs2228570
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the VDR Fok1 variant (rs2228570), selected for previously positive associations with MS susceptibility and 25(OH)D levels in MS patients showed marginally distorted transmission in DRB15-negative patients (p=0.03).
|
21440908 |
2011 |
|
rs2228570
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found weak evidence for an association between the rs731236C allele and MS, while there was no direct association with rs2228570.
|
21816760 |
2012 |
|
rs2228570
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study is to measure plasma levels of OPG and RANKL as well as to analyze VDR FokI polymorphism (rs2228570) in MS patients and healthy individuals to detect any potential correlation.
|
22805623 |
2012 |
|
rs2228570
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
A total of 9, 5, 3, and 7 studies were finally included in the analyses for the associations between the VDR TaqI (rs731236), FokI (rs2228570), ApaI (rs7975232), or aggrecan VNTR polymorphisms and the risk of IDD, respectively.
|
23209686 |
2012 |
|
rs2228570
|
|
Intervertebral disc disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
A total of 9, 5, 3, and 7 studies were finally included in the analyses for the associations between the VDR TaqI (rs731236), FokI (rs2228570), ApaI (rs7975232), or aggrecan VNTR polymorphisms and the risk of IDD, respectively.
|
23209686 |
2012 |
|
rs2228570
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Vitamin D receptor polymorphism rs2228570 (Fok1) is associated with rheumatoid arthritis in North American natives.
|
22859341 |
2012 |
|
rs2228570
|
|
Dengue Fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of T allele of rs2228570 in a dominant mode was significantly higher in DHF cases as compared to DF cases (P=0.034 OR 2.58).
|
22917542 |
2012 |
|
rs2228570
|
|
Mitral Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study is to measure plasma levels of OPG and RANKL as well as to analyze VDR FokI polymorphism (rs2228570) in MS patients and healthy individuals to detect any potential correlation.
|
22805623 |
2012 |
|
rs2228570
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed the association of genetic variants in VDR (rs731236, rs1989969, rs2228570, and 11568820) with breast cancer survival in a sample of 498 patients with breast cancer with a mean age at diagnosis of 61 years from Saarland, Germany, who were followed for up to 5 years with respect to total and breast cancer-specific mortality (56 and 48 events, respectively).
|
23300018 |
2013 |
|
rs2228570
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sunlight measures were not associated with breast cancer risk, however significant interactions between time outdoors in the teen years and three unlinked genotypes were found for VDR (rs1544410, rs2228570) and CYP24A1 (rs1570669).
|
23393347 |
2013 |
|
rs2228570
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sunlight measures were not associated with breast cancer risk, however significant interactions between time outdoors in the teen years and three unlinked genotypes were found for VDR (rs1544410, rs2228570) and CYP24A1 (rs1570669).
|
23393347 |
2013 |
|
rs2228570
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed the association of genetic variants in VDR (rs731236, rs1989969, rs2228570, and 11568820) with breast cancer survival in a sample of 498 patients with breast cancer with a mean age at diagnosis of 61 years from Saarland, Germany, who were followed for up to 5 years with respect to total and breast cancer-specific mortality (56 and 48 events, respectively).
|
23300018 |
2013 |