|
rs2228570
|
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045).
|
30730049 |
2019 |
|
rs2228570
|
|
Juvenile arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the influence of rs2228570 polymorphism on lipid profile and on outcome in patients with juvenile idiopathic arthritis (JIA) treated with etanercept.
|
30128913 |
2019 |
|
rs2228570
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
In Thai patients with chronic HCV infection, the bAt haplotype is associated with poor response to PEG-IFN-based therapy, and the <i>FokI</i> rs2228570 TT/TC genotypes are risk factors for advanced liver fibrosis.
|
31565578 |
2019 |
|
rs2228570
|
|
Leprosy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Some polymorphisms of the <i>VDR</i> gene, such as <i>Bsm</i>I (G>A rs1544410)<i>, Apa</i>I (G>T rs7975232), and <i>Taq</i>I (T>C rs731236) could affect its stability and mRNA transcription activity, while <i>Fok</i>I T>C (rs2228570) gives a truncated protein with three fewer amino acids and more efficiency in binding vitamin D. This study evaluated these four polymorphisms in the immunopathogenesis of leprosy in 404 patients and 432 control individuals without chronic or infectious disease in southern Brazil.
|
31636627 |
2019 |
|
rs2228570
|
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that VDR ApaI (rs7975232) and VDR BsmI (rs1544410) polymorphisms are correlated with susceptibility to PCOS in the Asian population and VDR TaqI (rs731236), VDR FokI (rs2228570), VDR Tru9I (rs757343) did not reveal a relationship with the PCOS susceptibility.
|
30764792 |
2019 |
|
rs2228570
|
|
Fibrosis, Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>FokI</i> rs2228570 TT/TC genotypes (OR = 1.63, 95% CI [1.06-2.51], <i>p</i> = 0.03) and age ≥55 years (OR = 2.25; 95% CI [1.54-3.32], <i>p</i> < 0.001) were independently associated with advanced liver fibrosis, assessed based on FIB-4 score >3.25.
|
31565578 |
2019 |
|
rs2228570
|
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that VDR rs1544410, rs2228570 and rs731236 variants might serve as genetic biomarkers of TB in certain populations.
|
30822458 |
2019 |
|
rs2228570
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Vitamin D receptor ApaI (rs7975232), BsmI (rs1544410), Fok1 (rs2228570), and TaqI (rs731236) gene polymorphisms and susceptibility to pulmonary tuberculosis in an Iranian population: A systematic review and meta-analysis.
|
31740220 |
2019 |
|
rs2228570
|
|
Osteopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of the TT allele of the SNP rs2228570 of the VDR gene and the SNP rs731236 of the CC genotype was associated with the presence of osteopenia and decreased bone mineral density alongside malfunctions of vitamin D.
|
30963970 |
2019 |
|
rs2228570
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that VDR rs731236 & rs2228570 or VDBP rs7041 polymorphisms were not risk factors for the development of gastric cancer individually, however, lower serum levels of vitamin D may be a contributory risk for both predisposition and development of gastric cancer.
|
31549372 |
2019 |
|
rs2228570
|
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the relationship between <i>VDR FokI</i> (rs2228570) single nucleotide polymorphism (SNP) and renal function and related clinicopathologic parameters in IgAN patients.
|
31218132 |
2019 |
|
rs2228570
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that VDR rs731236 & rs2228570 or VDBP rs7041 polymorphisms were not risk factors for the development of gastric cancer individually, however, lower serum levels of vitamin D may be a contributory risk for both predisposition and development of gastric cancer.
|
31549372 |
2019 |
|
rs2228570
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
rs2228570
|
|
Thromboangiitis Obliterans
|
|
0.010 |
GeneticVariation
|
BEFREE |
<i>Conclusions</i>: These preliminary results have shown that C allele of rs2228570 may contribute to the development of TAO in patients of Caucasian Polish origin.
|
31424978 |
2019 |
|
rs2228570
|
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusions:</b> Our meta-analysis supported that <i>VDR</i> rs2228570 variant might serve as a genetic biomarker of periodontitis.
|
30957605 |
2019 |
|
rs2228570
|
|
Sepsis of the newborn
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association of VDR polymorphism at FokI, rs2228570 T/C, and TaqI, rs731236 C/T gene with serum 25-hydroxyvitamin D level and risk of neonatal sepsis.
|
29530503 |
2018 |
|
rs2228570
|
|
Arteriovenous fistula
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the influence of the vitamin D receptor gene TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms in arteriovenous fistula failure in hemodialysis patients.
|
29544394 |
2018 |
|
rs2228570
|
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
The VDR rs2228570 variant may increase susceptibility to dyslipidemia in the Chinese Han population.
|
30119682 |
2018 |
|
rs2228570
|
|
Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms in the nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reductase-7 (rs3829251, rs12785878) and vitamin D receptor (rs2228570) genes were independently associated with increased steatosis; while a group-specific component variant (rs4588) was associated with increased inflammation in liver biopsies.
|
29761652 |
2018 |
|
rs2228570
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis was conducted to assess the association of VDR ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and Fok1 (rs2228570) gene polymorphisms with RCC risk.
|
29970659 |
2018 |
|
rs2228570
|
|
Chorioamnionitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2228570 T/T genotype associated with gestational diabetes mellitus (p=0.044) and chorioamnionitis during pregnancy (p=0.043).
|
29128634 |
2018 |
|
rs2228570
|
|
Autism Spectrum Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
This case-control study aimed to determine the association of single-nucleotide polymorphisms (SNPs) rs731276 (TaqI), rs1568820 (Cdx2), rs1544410 (BsmI), and rs2228570 (FokI) in the vitamin D receptor (VDR) gene with susceptibility of childhood ASD and severity of the disease.
|
29581796 |
2018 |
|
rs2228570
|
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
<i>VDR</i> rs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs2228570
|
|
CATARACT, ANTERIOR POLAR
|
|
0.010 |
GeneticVariation
|
BEFREE |
The VDR gene Fok I (rs2228570) polymorphism confers susceptibility to CAP in Egyptian children.
|
30135595 |
2018 |
|
rs2228570
|
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2228570 T/T genotype associated with gestational diabetes mellitus (p=0.044) and chorioamnionitis during pregnancy (p=0.043).
|
29128634 |
2018 |