|
rs2228570
|
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusions:</b> Our meta-analysis supported that <i>VDR</i> rs2228570 variant might serve as a genetic biomarker of periodontitis.
|
30957605 |
2019 |
|
rs2228570
|
|
Thromboangiitis Obliterans
|
|
0.010 |
GeneticVariation
|
BEFREE |
<i>Conclusions</i>: These preliminary results have shown that C allele of rs2228570 may contribute to the development of TAO in patients of Caucasian Polish origin.
|
31424978 |
2019 |
|
rs2228570
|
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
<i>VDR</i> rs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs2228570
|
|
Rickets
|
|
0.010 |
GeneticVariation
|
BEFREE |
16 studies were recruited for the analysis of the association between VDR BsmI (rs1544410), TaqI (rs731236), FokI (rs2228570) and ApaI (rs7975232) gene polymorphisms and the risk of rickets among Asians, most of whom were from China.
|
24336386 |
2014 |
|
rs2228570
|
|
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
: To investigate whether vitamin D receptor gene (<i>VDR</i>) BsmI-rs1544410 and FokI-rs2228570 polymorphisms, smoking duration, and body mass index (BMI) are risk factors for cutaneous melanoma, especially metastatic melanoma.
|
28884047 |
2017 |
|
rs2228570
|
|
Metastatic melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
: To investigate whether vitamin D receptor gene (<i>VDR</i>) BsmI-rs1544410 and FokI-rs2228570 polymorphisms, smoking duration, and body mass index (BMI) are risk factors for cutaneous melanoma, especially metastatic melanoma.
|
28884047 |
2017 |
|
rs2228570
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Diabetes duration, SBP, HbA1c, and the rs2228570 T allele were associated with increased risk of DR. VDR rs2228570 might be good candidate biomarker of DR in Han Chinese T2DM patients.
|
25899017 |
2015 |
|
rs2228570
|
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Diabetes duration, SBP, HbA1c, and the rs2228570 T allele were associated with increased risk of DR. VDR rs2228570 might be good candidate biomarker of DR in Han Chinese T2DM patients.
|
25899017 |
2015 |
|
rs2228570
|
|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A systematic review was conducted on the relationship between childhood asthma and VDR gene polymorphisms, including ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570), and TaqI (rs731236).
|
27551963 |
2017 |
|
rs2228570
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
A total of 9, 5, 3, and 7 studies were finally included in the analyses for the associations between the VDR TaqI (rs731236), FokI (rs2228570), ApaI (rs7975232), or aggrecan VNTR polymorphisms and the risk of IDD, respectively.
|
23209686 |
2012 |
|
rs2228570
|
|
Intervertebral disc disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
A total of 9, 5, 3, and 7 studies were finally included in the analyses for the associations between the VDR TaqI (rs731236), FokI (rs2228570), ApaI (rs7975232), or aggrecan VNTR polymorphisms and the risk of IDD, respectively.
|
23209686 |
2012 |
|
rs2228570
|
|
Sporadic Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association with the minor allele A of the non-synonymous SNP rs2228570 (rs10735810, FokI, Met1Thr) was observed for BC, with an estimated odds ratio (OR) of 1.26 (95% CI = 1.02-1.57; p = 0.036).
|
19105801 |
2008 |
|
rs2228570
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of FokI (rs2228570) and BsmI (rs1544410) single nucleotide polymorphisms (SNPs) in VDR gene with the risk of breast cancer have been investigated in several studies, however, the published data are still inconsistent.
|
28780723 |
2018 |
|
rs2228570
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of FokI (rs2228570) and BsmI (rs1544410) single nucleotide polymorphisms (SNPs) in VDR gene with the risk of breast cancer have been investigated in several studies, however, the published data are still inconsistent.
|
28780723 |
2018 |
|
rs2228570
|
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Besides, the risk of asthma progression was increased in patients with the VDR rs2228570 CC and VDBP rs7041 GG genotypes (OR = 3.56, P = .0382 and OR = 2.58, P = .01, respectively).
|
31541492 |
2020 |
|
rs2228570
|
|
Osteoporosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Both VDR-rs2228570-T and OPG-rs3102735-G and their interactions are related to the increased risk of osteoporosis.
|
30624097 |
2019 |
|
rs2228570
|
|
Cutaneous Melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
BsmI (rs1544410) and FokI (rs2228570) vitamin D receptor polymorphisms, smoking, and body mass index as risk factors of cutaneous malignant melanoma in northeast Italy.
|
28884047 |
2017 |
|
rs2228570
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
rs2228570
|
|
Liver diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Combining VDR rs2228570 A/A genotype with IL28B C/C genotype increased the probability of SVR from 82 % to reach 100 % and from 29 % to reach 80 % in C/T+ T/T IL28B genotype in none F4 liver disease patients.
|
26911666 |
2016 |
|
rs2228570
|
|
Fatty Liver Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Donor/recipient CYP27A1 rs4674344 and graft VDR rs2228570 may be related to low serum 25(OH)D and may play a major role in the development of fatty liver disease in recipients after living donor liver transplantation.
|
29935100 |
2018 |
|
rs2228570
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
For example, breast cancer risk was associated with the GC rs7041 TT genotype (age-adjusted odds ratio (OR) = 1.23; 95% CI: 1.01, 1.51) and inversely with the VDR Fok1 (rs2228570) ff genotype (OR = 0.71; 95% CI: 0.57, 0.88).
|
21693626 |
2011 |
|
rs2228570
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
For example, breast cancer risk was associated with the GC rs7041 TT genotype (age-adjusted odds ratio (OR) = 1.23; 95% CI: 1.01, 1.51) and inversely with the VDR Fok1 (rs2228570) ff genotype (OR = 0.71; 95% CI: 0.57, 0.88).
|
21693626 |
2011 |
|
rs2228570
|
|
Aplastic Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further analysis indicated that rs1544410 and rs7975232 polymorphisms were correlated with the risk to nonsevere AA, while rs2228570 was relevant to severe AA.
|
27018192 |
2016 |
|
rs2228570
|
|
Chronic Periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Further subgroup analyses yielded similar positive results for rs2228570 variant in East Asians and patients with chronic periodontitis.
|
30957605 |
2019 |
|
rs2228570
|
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Furthermore, we found that the rs2228570 genotype (OR, 3.763) of the VDR SNP and the vitamin D concentration (lower than 40 ng/ml, OR: 38.938) both contribute to increased susceptibility to bronchial asthma.
|
31719947 |
2019 |