|
rs17576
|
|
Adult Fibrosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
With the exception of one amino-acid substitution at position 280 (Arg-->Gln), the deduced amino-acid sequences of neutrophil gelatinase are identical to the amino-acid sequences of the enzyme isolated from fibrosarcoma cells.
|
8305481 |
1994 |
|
rs17576
|
|
Agenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms in the MMP2 (rs243865), MMP9 (rs17576), and MMP13 (rs2252070) genes with tooth agenesis in humans.
|
24351915 |
2013 |
|
rs2664538
|
|
Allergic asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNP rs2664538 significantly increased the risk for non-atopic wheezing (OR 2.12, 95%CI 1.40-3.21, p < 0.001) and non-atopic asthma (OR 1.66, 95%CI 1.12-2.46, p = 0.011).
|
20181264 |
2010 |
|
rs17577
|
|
Allergic asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
2127G>T and 5546G>A (R668Q) were significantly associated with the risk of childhood atopic asthma (p = 0.0032 and 0.0016, respectively).
|
16631427 |
2006 |
|
rs2664538
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD.
|
15748780 |
2005 |
|
rs2274756
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD.
|
15748780 |
2005 |
|
rs2250889
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD.
|
15748780 |
2005 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population.
|
19633731 |
2009 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan.
|
23441116 |
2013 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls.
|
31713905 |
2020 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs3918249
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
|
rs3918249
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs2664538
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results reveal that SNP rs2664538, which is located at the MMP9 gene, is likely to be associated with acute PACG.
|
17110919 |
2006 |
|
rs2664538
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study did not find an association between the rs2664538 polymorphism within the MMP-9 gene and PACG in this sample of Chinese subjects.
|
18552608 |
2008 |
|
rs2250889
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Heterozygotes (GC) and allele "G" for rs2250889 polymorphism were more frequent in PACG cases compared with healthy controls (GC: P < .0001, OR = 2.26; G: P < .0001, OR = 1.19).
|
31713905 |
2020 |
|
rs2250889
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP rs2250889 located in MMP-9 might be associated with PACG among southern Chinese people, and people with the G/G genotype are likely more susceptible to PACG.
|
19633731 |
2009 |
|
rs17577
|
|
Angle Closure Glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs3918242
|
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four single nucleotide polymorphisms (SNPs) in the human homologues of these genes were significantly associated with susceptibility for anxiety disorders (MMP9: rs3918242 and BDNF: rs6265, rs10835210 and rs11030107).
|
29288745 |
2018 |
|
rs3918242
|
|
Aortic Aneurysm, Abdominal
|
|
0.020 |
GeneticVariation
|
BEFREE |
No associations with AAA were identified for other SNPs assessed in this study including rs1799750 (MMP1), rs3918242 (MMP9), rs486055 (MMP10), rs2276109 (MMP12), rs2252070 (MMP13), rs4898 (TIMP1) or rs9619311 (TIMP3).
|
23813847 |
2014 |
|
rs3918242
|
|
Aortic Aneurysm, Abdominal
|
|
0.020 |
GeneticVariation
|
BEFREE |
We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (-1561C/T; rs3918242) and MMP13 (-77A/G; rs2252070), and the presence of large AAAs.
|
29739236 |
2019 |
|
rs8125581
|
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses identified MMP-9 p-2502 single nucleotide polymorphism (odds ratio [OR], 0.54; 95% confidence interval [CI], 0.31-0.94; P = .029) as a significant confound discriminating between control vs slow-growth AAA, MMP-9 D165N (OR, 0.49; 95% CI, 0.26-0.95; P = .035) and LRP1 (OR, 4.99; 95% CI, 1.13-22.1; P = .034) between control vs aggressive-growth AAAs, and methyltetrahydrofolate reductase (OR, 2.99; 95% CI, 1.01-8.86; P = .048), MMP-9 p-2502 (OR, 2.19; 95% CI, 1.05-4.58; P = .037), and LRP1 (OR, 4.96; 95% CI, 1.03-23.9; P = .046) as the statistically significant confounds distinguishing slow-growth AAAs vs aggressive-growth AAAs.
|
24801553 |
2014 |
|
rs2234681
|
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
MMP9 rs2234681 microsatellite was the only genetic determinant of TE/A in AAA patients (P = .003), followed by hypercholesterolemia and antiplatelet use.
|
29291905 |
2018 |
|
rs201191171
|
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
For those polymorphisms independently associated with AAA in this study (-1306C/T MMP2, 5A/6A MMP3, -77A/G MMP-13, and G1355A ELN polymorphisms), we performed a meta-analysis of the available data (this paper and literature data).
|
22094117 |
2012 |