|
rs1056628
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, whether rs1056628 SNP in miR-491-5p binding site of MMP9 3'-UTR could abrogate its post-transcriptional regulation and affect cancer susceptibility remains largely unknown.
|
29091292 |
2018 |
|
rs1056628
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, whether rs1056628 SNP in miR-491-5p binding site of MMP9 3'-UTR could abrogate its post-transcriptional regulation and affect cancer susceptibility remains largely unknown.
|
29091292 |
2018 |
|
rs13925
|
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The main finding of our study is the association of MMP9 genotypes rs20544 TT and rs13925 AA and AG with better asthma control, and indirectly better response to treatment.
|
29600353 |
2018 |
|
rs139620474
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Point mutations in the collagen-like domain (R32C, G34D, or G37E) of MBL cause a serum deficiency, predisposing patients to infections and diseases such as rheumatoid arthritis.
|
11891230 |
2002 |
|
rs1430059719
|
|
Fibrosis, Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, adenoviral application of the mutants MMP-9-H401A and -E402Q led to increased apoptosis of activated hepatic stellate cells, thought to be the main promoters of hepatic fibrosis.
|
16507762 |
2006 |
|
rs1459997671
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
For MMP9 -1,562 C/T, a borderline effect was found with digestive cancers in the total and stratified analysis of the colorectal cancer under dominant model.
|
23644699 |
2013 |
|
rs1459997671
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
For MMP9 -1,562 C/T, a borderline effect was found with digestive cancers in the total and stratified analysis of the colorectal cancer under dominant model.
|
23644699 |
2013 |
|
rs1459997671
|
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MMP-1 -1,607 1G/2G (rs1799750), MMP-2 -1,306 C/T (rs243865), and MMP-9 -1,562 C/T (rs3918242) polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism assay in 157 patients diagnosed with knee osteoarthritis based on the criteria of American College of Rheumatology and in 84 controls in Mersin, Turkey.
|
18802702 |
2009 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
We explored the association of MMP2 (C-735T, rs2285053), MMP7 (A-181G, rs11568818) and MMP9 (R279Q, rs17576), (P574R, rs2250889), (R668Q, rs17577) genetic variants with LVD in coronary artery disease (CAD) patients.
|
22664146 |
2012 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
These findings suggest that MMP-9 R279Q, P574R and R668Q may have combined effect in the occurrence of CAD and -1562 CT/TT genotypes may contribute to CAD in diabetics and MI in CAD patients.
|
19283512 |
2010 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
And some studies have reported that the G allele of rs17576 might be associated with CAD.
|
23819814 |
2013 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence that genetic polymorphism of MMP1-1607 1G/2G, MMP3-Gly45lys, MMP3-376 G/C, MMP3-1171 5A/6A, MMP9-1562 C/T and MMP9-R279Q have a small to medium effect on incidence of coronary disease.
|
22226810 |
2012 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The promoter -1562C/T and exon 6 R279Q A/G polymorphisms were determined in 1001 patients with angiographically verified stable CAD and in 204 healthy controls.
|
21963461 |
2012 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population.
|
19633731 |
2009 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population.
|
19633731 |
2009 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan.
|
23441116 |
2013 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan.
|
23441116 |
2013 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls.
|
31713905 |
2020 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls.
|
31713905 |
2020 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs17576
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16).
|
23328249 |
2013 |