|
rs17576
|
|
Adult Fibrosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
With the exception of one amino-acid substitution at position 280 (Arg-->Gln), the deduced amino-acid sequences of neutrophil gelatinase are identical to the amino-acid sequences of the enzyme isolated from fibrosarcoma cells.
|
8305481 |
1994 |
|
rs17576
|
|
Fibrosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
With the exception of one amino-acid substitution at position 280 (Arg-->Gln), the deduced amino-acid sequences of neutrophil gelatinase are identical to the amino-acid sequences of the enzyme isolated from fibrosarcoma cells.
|
8305481 |
1994 |
|
rs139620474
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Point mutations in the collagen-like domain (R32C, G34D, or G37E) of MBL cause a serum deficiency, predisposing patients to infections and diseases such as rheumatoid arthritis.
|
11891230 |
2002 |
|
rs17576
|
|
Stable angina
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although none of the polymorphisms was significantly related with future CV death, there was a significant association (P=0.02) between the R279Q polymorphism and CV events in patients with stable angina.
|
12668489 |
2003 |
|
rs17576
|
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
MMP-9 -1562C>T and 836G>A (Arg279Gln) were not associated with asthma (p> or =0.15) or asthma severity (p> or =0.13), and TIMP-1 434T>C (Phe124Phe) was not associated with asthma in women (p = 0.094) or men (p = 0.207).
|
16061701 |
2005 |
|
rs17576
|
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We were interested in whether the polymorphisms -T1702A, -C1562T, R279Q and +C6T within the matrix metalloproteinase 9 (MMP-9) gene were associated with asthma in a population of 231 asthmatic children.However, we found no association.
|
16026590 |
2005 |
|
rs2250889
|
|
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
|
rs17577
|
|
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
To test our hypothesis that common nonsynonymous SNPs, R279Q, P574R, and R668Q, in MMP-9 are associated with lung cancer development and metastasis, we conducted a case-control study of 744 patients with incident lung cancer and 747 cancer-free controls in Southeast China.
|
16061858 |
2005 |
|
rs17576
|
|
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
These findings indicate that the potentially functional polymorphisms, MMP-9 P574R and R279Q, may confer the biomarker in the occurrence and metastasis of primary lung cancer.
|
16061858 |
2005 |
|
rs2664538
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD.
|
15748780 |
2005 |
|
rs2274756
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD.
|
15748780 |
2005 |
|
rs2250889
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD.
|
15748780 |
2005 |
|
rs2250889
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
|
rs2250889
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
|
rs2250889
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
|
rs17577
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no overall significant associations were observed between R668Q and lung cancer risk in this study population.
|
16061858 |
2005 |
|
rs17577
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no overall significant associations were observed between R668Q and lung cancer risk in this study population.
|
16061858 |
2005 |
|
rs17577
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no overall significant associations were observed between R668Q and lung cancer risk in this study population.
|
16061858 |
2005 |
|
rs17576
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
|
rs17576
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
|
rs17576
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
|
rs2664538
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results reveal that SNP rs2664538, which is located at the MMP9 gene, is likely to be associated with acute PACG.
|
17110919 |
2006 |
|
rs2664538
|
|
Primary angle-closure glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results reveal that SNP rs2664538, which is located at the MMP9 gene, is likely to be associated with acute PACG.
|
17110919 |
2006 |
|
rs17577
|
|
IgE-mediated allergic asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
2127G>T and 5546G>A (R668Q) were significantly associated with the risk of childhood atopic asthma (p = 0.0032 and 0.0016, respectively).
|
16631427 |
2006 |
|
rs17577
|
|
Allergic asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
2127G>T and 5546G>A (R668Q) were significantly associated with the risk of childhood atopic asthma (p = 0.0032 and 0.0016, respectively).
|
16631427 |
2006 |