|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) strongly predicts sustained virological response to pegylated interferon plus ribavirin (pegIFN-RBV) treatment for chronic hepatitis C virus (HCV) infection.
|
20964522 |
2010 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs12979860 SNP located near the IL28B gene is associated with HCV treatment response in HIV-infected patients with chronic hepatitis C due to genotypes 1 or 4.
|
20389235 |
2010 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
With the screening for IL28B polymorphisms rs12980275, rs8099917 and rs12979860, which are associated with HCV chronicity and with reduced SVR rates, an important prognostic factor of the therapy of chronic hepatitis C can be easily diagnosed.
|
21149916 |
2010 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients requiring liver transplantation due to end-stage chronic hepatitis C appeared to be selected toward the adverse genotypes rs12979860 CT/TT compared to non-transplanted HCV-infected patients (p=0.046).
|
21147186 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene.
|
21703198 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B genotype is the most important pretreatment predictor of treatment outcome in patients with chronic hepatitis C. The impact of the rs12979860 genotype on relapse was retrospectively evaluated in genotype 1/4 patients who received response-guided therapy with peginterferon alpha-2a 180 μg/week plus ribavirin 1,000/1,200 mg/day in a large, randomized, multicenter study.
|
22006276 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
41 patients with genotype 1 chronic hepatitis C infection from the Duke Liver Clinic were genotyped for rs12979860.
|
21750736 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped chronic hepatitis C (CHC) genotype 1 patients with PegIFN/R treatment-induced clearance (n = 417) and treatment failure (n = 493), and 234 individuals with spontaneous clearance, for HLA-C C1 versus C2, presence of inhibitory and activating KIR genes, and two IL28B SNPs, rs8099917 and rs12979860.
|
21931540 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Vitamin D serum levels are complementary to the IL-28B rs12979860 C/T polymorphism in enhancing the correct prediction of the SVR in treatment-naïve chronic hepatitis C.
|
21480318 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Role of interleukin 28B rs12979860 C/T polymorphism on the histological outcome of chronic hepatitis C: relationship with gender and viral genotype.
|
21647799 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results demonstrate that the genotypes rs12979860 CC and rs8099917 TT were more frequently observed in Korean patients compared to other ethnicities, and suggest that the genetic characteristics of patients may be prognostic factor that predicts antiviral response to PEG-IFN therapy for chronic hepatitis C.
|
21907615 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The mechanism explaining the strong association between IL28B rs12979860 polymorphisms and treatment outcome in chronic hepatitis C remains unclear.
|
22294646 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Frequency of IL28B rs12979860 single-nucleotide polymorphism alleles in newborn infants and in patients with chronic hepatitis C in Morocco.
|
22509814 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in IL28B and serum levels of interferon γ inducible protein 10 (IP-10) predict outcomes of antiviral therapy in patients with chronic hepatitis C. We associated IL28B SNPs rs12979860 and rs8099917, along with serum levels of IP-10, with outcomes of patients with acute hepatitis C (AHC).
|
22192885 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The interleukin 28B rs12979860 C/T polymorphism and serum cholesterol as predictors of fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases.
|
22431022 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C.
|
22666430 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To evaluate the effect of single nucleotide polymorphisms of interleukin (IL)-28B, rs12979860 on progression and treatment response in chronic hepatitis C.
|
23002361 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To determine, in a cohort of Spanish patients with chronic hepatitis C treated with peginterferon plus ribavirin (P+R), whether insulin resistance predicts SVR independently of interleukin-28B rs12979860 polymorphism.
|
23121166 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C.
|
23220171 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients with advanced liver disease carried the rs12979860-T/T genotype more frequently than patients with mild chronic hepatitis C (OR = 1.89; 95% CI, 0.99-3.61; p = 0.0532) and this risk was even more pronounced when we compared them with healthy controls (OR = 4.27; 95% CI, 2.08-8.76; p = 0.0005).
|
23358556 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients.
|
23440114 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B genotype in rs12979860 predicts success of peginterferon/ribavirin (PEG/RBV) therapy in patients with chronic hepatitis C (CHC).
|
24205831 |
2014 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies revealed the rs12979860 single nucleotide polymorphism (SNP) of the IL28B gene (CC genotype) to be the strongest pre-therapeutic predictor of therapy response to interferon alpha in patients with chronic hepatitis C infection.
|
25389973 |
2014 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To assess the role of the ss469415590 variant, compared with the known IL28B polymorphisms (rs8099917, rs12979860 and rs12980275) for predicting virological response to therapy in chronic hepatitis C, and its association with the CXCL10 chemokine serum levels - a surrogate marker of interferon-stimulated genes activation.
|
24308755 |
2014 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent studies in chronic hepatitis C patients have shown that rs368234815 polymorphism nearby IL28B is a better predictor of response to antiviral treatment with pegylated interferon and ribavirin than IL28B polymorphisms (rs12979860 and rs8099917).
|
25130512 |
2014 |