|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
41 patients with genotype 1 chronic hepatitis C infection from the Duke Liver Clinic were genotyped for rs12979860.
|
21750736 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A comparative study of various methods for detection of IL28B rs12979860 in chronic hepatitis C.
|
28281380 |
2017 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significant increase was observed in the frequencies of unfavorable rs12979860 genotypes/CT + TT in the chronic hepatitis C (CHC) and LTC groups.
|
28214926 |
2017 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) strongly predicts sustained virological response to pegylated interferon plus ribavirin (pegIFN-RBV) treatment for chronic hepatitis C virus (HCV) infection.
|
20964522 |
2010 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although the single-nucleotide polymorphism (SNP) rs12979860 in the IL28B gene is a better predictor of sustained virological response to treatment of chronic hepatitis C (CHC) than other baseline factors, some CHC patients with the favorable C allele cannot achieve a sustained virological response when treated with peginterferon plus ribavirin.
|
25687192 |
2015 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Duplex High-Resolution Melting Assay for the Simultaneous Genotyping of IL28B rs12979860 and PNPLA3 rs738409 Polymorphisms in Chronic Hepatitis C Patients.
|
26389885 |
2015 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C.
|
23220171 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Frequency of IL28B rs12979860 single-nucleotide polymorphism alleles in newborn infants and in patients with chronic hepatitis C in Morocco.
|
22509814 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
IL28B polymorphism (rs12979860) associated with clearance of HCV infection in Poland: systematic review of its prevalence in chronic hepatitis C patients and general population frequency.
|
25712648 |
2015 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
IL28B SNP rs12979860 is the Critical Predictor for Sustained Viral Response in Chinese Children Aged 1 to 6 Years with Chronic Hepatitis C.
|
27877087 |
2016 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Impact of IFNL4 rs12979860 and rs8099917 polymorphisms on response to Peg-Interferon-α and Ribavirin in patients with congenital bleeding disorder and chronic hepatitis C.
|
27735085 |
2017 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients requiring liver transplantation due to end-stage chronic hepatitis C appeared to be selected toward the adverse genotypes rs12979860 CT/TT compared to non-transplanted HCV-infected patients (p=0.046).
|
21147186 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients with advanced liver disease carried the rs12979860-T/T genotype more frequently than patients with mild chronic hepatitis C (OR = 1.89; 95% CI, 0.99-3.61; p = 0.0532) and this risk was even more pronounced when we compared them with healthy controls (OR = 4.27; 95% CI, 2.08-8.76; p = 0.0005).
|
23358556 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Polymorphisms of inosine triphosphate pyrophosphatase (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C on ribavirin/interferon.
|
31359493 |
2020 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies revealed the rs12979860 single nucleotide polymorphism (SNP) of the IL28B gene (CC genotype) to be the strongest pre-therapeutic predictor of therapy response to interferon alpha in patients with chronic hepatitis C infection.
|
25389973 |
2014 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent studies in chronic hepatitis C patients have shown that rs368234815 polymorphism nearby IL28B is a better predictor of response to antiviral treatment with pegylated interferon and ribavirin than IL28B polymorphisms (rs12979860 and rs8099917).
|
25130512 |
2014 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Role of interleukin 28B rs12979860 C/T polymorphism on the histological outcome of chronic hepatitis C: relationship with gender and viral genotype.
|
21647799 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in IL28B and serum levels of interferon γ inducible protein 10 (IP-10) predict outcomes of antiviral therapy in patients with chronic hepatitis C. We associated IL28B SNPs rs12979860 and rs8099917, along with serum levels of IP-10, with outcomes of patients with acute hepatitis C (AHC).
|
22192885 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs12979860 SNP located near the IL28B gene is associated with HCV treatment response in HIV-infected patients with chronic hepatitis C due to genotypes 1 or 4.
|
20389235 |
2010 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of the study was to evaluate the association between three most widely studied IL28B gene polymorphisms and the response to antiviral treatment of chronic hepatitis C. We performed the genotyping of the three IL28B gene polymorphisms: rs12979860, rs8099917, and rs12980275 in 72 Caucasian patients with chronic hepatitis C, previously treated with the combination therapy of pegylated interferon alpha (PEGIFN α) and ribavirin (RBV).
|
26614853 |
2015 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients.
|
23440114 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the relationship between IL28B rs12979860 genotype, the level of TNFα activation and the degree of IR in patients with chronic hepatitis C. One hundred and thirty-three nondiabetic genotype 1 HCV-infected patients with biopsy proven noncirrhotic hepatitis C were investigated for IR (using HOMA index), IL28B rs12979860 genotype and fasting circulating levels of soluble receptor 1 of TNFα (sTNFR1) and adipokines: leptin, adiponectin and IL-6.
|
25818002 |
2015 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C.
|
22666430 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B genotype in rs12979860 predicts success of peginterferon/ribavirin (PEG/RBV) therapy in patients with chronic hepatitis C (CHC).
|
24205831 |
2014 |