Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1052133
rs1052133
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 GeneticVariation BEFREE We, therefore, examined allele distributions of the Ser326Cys polymorphism in a case-control study of male lung cancer in Okinawa. 10744126

1999

dbSNP: rs1052133
rs1052133
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.100 GeneticVariation BEFREE We, therefore, examined allele distributions of the Ser326Cys polymorphism in a case-control study of male lung cancer in Okinawa. 10744126

1999

dbSNP: rs1052133
rs1052133
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE We, therefore, examined allele distributions of the Ser326Cys polymorphism in a case-control study of male lung cancer in Okinawa. 10744126

1999

dbSNP: rs1052133
rs1052133
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung
0.010 GeneticVariation BEFREE Although our sample size was limited, these results indicate that the Ser326Cys variant may be related to squamous cell lung cancer susceptibility. 10744126

1999

dbSNP: rs1052133
rs1052133
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus
0.030 GeneticVariation BEFREE Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population. 11307145

2001

dbSNP: rs1052133
rs1052133
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma
0.030 GeneticVariation BEFREE Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population. 11307145

2001

dbSNP: rs1052133
rs1052133
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.030 GeneticVariation BEFREE Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population. 11307145

2001

dbSNP: rs1052133
rs1052133
Squamous cell carcinoma of esophagus
0.020 GeneticVariation BEFREE We investigated the association between Ser326Cys polymorphism and squamous-cell carcinoma of the esophagus among a Chinese population. hOGG1 gene polymorphism was detected by PCR-based single-strand conformation polymorphism and DNA sequencing among 201 normal controls and 196 patients with esophageal cancer from Linxian, China, a high-risk area for the disease. 11307145

2001

dbSNP: rs1052133
rs1052133
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE We examined the distribution of the hOGG1 Ser326Cys polymorphism and its presumed correlation with gastric cancer risk in two case-control studies of different ethnic groups in São Paulo, Brazil. 11448535

2001

dbSNP: rs1052133
rs1052133
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE We examined the distribution of the hOGG1 Ser326Cys polymorphism and its presumed correlation with gastric cancer risk in two case-control studies of different ethnic groups in São Paulo, Brazil. 11448535

2001

dbSNP: rs1052133
rs1052133
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.100 GeneticVariation BEFREE Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk. 11927502

2002

dbSNP: rs1052133
rs1052133
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk. 11927502

2002

dbSNP: rs1052133
rs1052133
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 GeneticVariation BEFREE Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk. 11927502

2002

dbSNP: rs1052133
rs1052133
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE These results suggest that hOGG1 may play an important role in the repair of 8-OH-dG adducts in the aerodigestive tract and that the hOGG1 Ser326Cys polymorphism plays an important role in risk for smoking- and alcohol-related orolaryngeal cancer. 12117782

2002

dbSNP: rs1052133
rs1052133
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE These results suggest that hOGG1 may play an important role in the repair of 8-OH-dG adducts in the aerodigestive tract and that the hOGG1 Ser326Cys polymorphism plays an important role in risk for smoking- and alcohol-related orolaryngeal cancer. 12117782

2002

dbSNP: rs1052133
rs1052133
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.050 GeneticVariation BEFREE In this study, polymorphisms in five genes involved in the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro187Ser, GSTT1-positive/null, GSTM1-positive/null, CYP1A1-Ile462Val, and OGG1-Ser326Cys, were examined for association with lung adenocarcinoma risk in a case-control study of 198 patients and 152 control subjects. 12163326

2002

dbSNP: rs1052133
rs1052133
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999; 8: 669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma. 12164330

2002

dbSNP: rs1052133
rs1052133
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999; 8: 669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma. 12164330

2002

dbSNP: rs1052133
rs1052133
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.050 GeneticVariation BEFREE This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999; 8: 669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma. 12164330

2002

dbSNP: rs1052133
rs1052133
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Nonetheless, published data were consistent with associations between: (a) the OGG1 S326C variant and increased risk of various types of cancer; (b) the XRCC1 R194W variant and reduced risk of various types of cancer; and (c) the BRCA2 N372H variant and increased risk of breast cancer. 12496039

2002

dbSNP: rs1052133
rs1052133
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Nonetheless, published data were consistent with associations between: (a) the OGG1 S326C variant and increased risk of various types of cancer; (b) the XRCC1 R194W variant and reduced risk of various types of cancer; and (c) the BRCA2 N372H variant and increased risk of breast cancer. 12496039

2002

dbSNP: rs1052133
rs1052133
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE Nonetheless, published data were consistent with associations between: (a) the OGG1 S326C variant and increased risk of various types of cancer; (b) the XRCC1 R194W variant and reduced risk of various types of cancer; and (c) the BRCA2 N372H variant and increased risk of breast cancer. 12496039

2002

dbSNP: rs1052133
rs1052133
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Nonetheless, published data were consistent with associations between: (a) the OGG1 S326C variant and increased risk of various types of cancer; (b) the XRCC1 R194W variant and reduced risk of various types of cancer; and (c) the BRCA2 N372H variant and increased risk of breast cancer. 12496039

2002

dbSNP: rs1052133
rs1052133
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.040 GeneticVariation BEFREE These results suggest that the hOGG1 Ser326Cys polymorphism is probably not a major contributor to individual colon cancer susceptibility overall, but the Cys/Cys genotype may alter the impact of some environmental factors on colon cancer development. 12717837

2003

dbSNP: rs1052133
rs1052133
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.030 GeneticVariation BEFREE These results suggest that the hOGG1 Ser326Cys polymorphism is probably not a major contributor to individual colon cancer susceptibility overall, but the Cys/Cys genotype may alter the impact of some environmental factors on colon cancer development. 12717837

2003