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rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated DNA methylation of the MDR1 gene in ulcerative colitis (UC) and its relation to MDR1 C3435T genotypes.Eighty-three UC patients were enrolled.
|
19288029 |
2009 |
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rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele frequencies and genotype distributions of the C3435T single nucleotide polymorphism were investigated in 149 patients with ulcerative colitis, 126 patients with Crohn's disease, and sex-matched healthy controls.
|
12512026 |
2003 |
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rs1045642
|
|
Leukopenia
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|
0.100 |
GeneticVariation
|
BEFREE |
Statistical associations were observed, suggesting a lower risk of neutropenia (p = 0.013) and hand-foot syndrome (HFS; p = 0.027) for the carriers of T variation for rs1128503 in capecitabine-treated patients, carriers of T variation for rs1045642 treated with capecitabine had a lower risk of HFS (p = 0.033), while those treated with 5-FU had a higher risk of diarrhea (p = 0.035), and carriers of T variation for rs2032592 treated with capecitabine were at less risk of developing HFS (p = 0.033).
|
21142915 |
2010 |
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rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele frequencies of the cyclooxygenase 2 (COX-2/PTGS2/PGHS2) G-765C and breast cancer resistance protein (BCRP/ABCG2) C421A as well as allele and haplotype frequencies of multidrug resistance 1 (MDR1, ABCB1) SNPs G2677T/A, C3435T and G-rs3789243-A (intron 3) were assessed in a Danish case-control study comprising 373 CD and 541 UC patients and 796 healthy controls.
|
18819034 |
2009 |
|
rs1045642
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a matched case-control study, we investigated the associations between CNS relapse in childhood ALL and the presence of phenotypically relevant single nucleotide polymorphisms within the GSTP1 (codon 105 and 114) and MDR1 genes (ABCB1; coding for Pgp; exon 26, C3435T).
|
15717687 |
2005 |
|
rs1045642
|
|
Leukopenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Serum LDH may be a promising predictor of prognosis, and the ABCB1 C3435T polymorphism may be a genetic predictor of the severity of leukocytopenia in patients with CRPC treated with DEC.
|
21706123 |
2012 |
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rs1045642
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C3435T polymorphism of the MDR1 gene may influence the transport and excretion of carcinogens, increasing the risk of cancer.
|
22641402 |
2012 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have noted that the implication of C3435T</span> variant on the risk of breast cancer was ethnicity-dependent.
|
27580695 |
2016 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the MDR1 C3435T polymorphism may contribute to individual susceptibility to breast cancer.
|
24070710 |
2013 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Besides, stratified analysis by clinical type also indicated that no significant association between MDR1 C3435T and the risk of Crohn's disease and ulcerative colitis was observed.
|
24449364 |
2014 |
|
rs1045642
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the influence of the MDR1 C3435T polymorphism on the development of childhood acute lymphoblastic leukemia (ALL), we studied 107 children with ALL and 111 healthy subjects.
|
19317599 |
2008 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed that the ABCB1 C3435T and G2677T/A variants as well as the 3435T-1236T-2677T haplotype significantly increased the risk of CRC.
|
23746184 |
2013 |
|
rs1045642
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, association between the MDR1 C3435T polymorphism and the cancer susceptibility was shown.
|
17300681 |
2007 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to explore the possible influence of CYP2C9 (*2, *3 and IVS8-109 A>T), CYP2C19 (*2, *3 and *17) and ABCB1 (1236C>T, 2677G>A/T and 3435C>T) on phenytoin (PHT) plasma concentrations in 64 Mexican Mestizo (MM) patients with epilepsy currently treated with PHT in mono- (n=25) and polytherapy (n=39).
|
26122019 |
2016 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ABCB1 3435C>T polymorphism and type of epilepsy were associated with response to PB.
|
25846690 |
2015 |
|
rs1045642
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggested that the MDR1 C3435T polymorphism may contribute to cancer risk.
|
22311042 |
2012 |
|
rs1045642
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the incidence of C3435T polymorphisms at exon 26 in the MDR-1 gene in 92 women with breast cancer and potential association of altered genotypes with smoking and high body mass index in cancer development among patients.
|
17549370 |
2007 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy with the consideration of 4 different criteria for qualification to groups sensitive and resistant to applied pharmacotherapy.
|
25223475 |
2014 |
|
rs1045642
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, the SNPs considered individually or within haplotypes (C1236T-G2677T/A-C3435T) were not significantly associated with childhood ALL.
|
17548681 |
2007 |
|
rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Finally, active UC in patients carrying the TLR2-R753Q and MDR1-C3435T polymorphisms was associated with increased nuclear expression of caspase-1 protein and cell death in areas of acute inflammation, compared with active UC patients without these variants.
|
23636052 |
2013 |
|
rs1045642
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL.
|
23244145 |
2012 |
|
rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNPs), C3435T and G2677T/A, thought to alter the function of the corresponding P-glycoprotein, have shown inconsistent associations with CD.
|
19107781 |
2009 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC).
|
20533057 |
2010 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the ABCB1 C3435T polymorphism may be a genetic marker for drug resistance in epilepsy in Caucasian populations.
|
25799371 |
2015 |