|
rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The analysis showed marginal significant association for the C3435T variant in UC: the risk estimate for the allele contrast was OR = 1.11 (1.00-1.22) and OR(G) = 1.12 (1.01-1.27), indicating that a subject with high mutational load has a 12% higher probability of being diseased.
|
21887726 |
2012 |
|
rs1045642
|
|
Leukopenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that patients carrying the CYP3A5*1/*3 genotype demonstrated more side effects of fever, pleural effusion, and febrile neutropenia than those with the CYP3A5*3/*3 genotype (p = 0.075, 0.077, and 0.030, respectively); moreover, patients with the ABCB1 2677G/G genotype also showed more side effects of fever and febrile neutropenia than those with other genotypes (p = 0.024 and 0.027), In regard to ABCB1 3435C>T, patients with ABCB1 3435C/C tended to suffer leucopenia (p = 0.057).
|
19332043 |
2009 |
|
rs1045642
|
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Controversy has surrounded the reported association of the single nucleotide polymorphism (SNP) C3435T of the ATP-binding cassette subfamily B member 1 (ABCB1, MDR1) gene, with refractory epilepsy.
|
17125969 |
2007 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
|
17917461 |
2008 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Heterozygous carriers for C3435T were significantly less likely to have CD (p=0.02; OR 0.58, 95% CI (0.36-0.91)).
|
23537364 |
2013 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
ABCB1 3435C>T and 2677G>T/A polymorphisms in Polish and Bosnian patients with Crohn's disease - A preliminary report.
|
28759738 |
2017 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study suggest that C3435T MDR1 polymorphism has an association with colorectal cancer.
|
20127181 |
2011 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study was aimed to evaluate the possible effects of ABCB1 C3435T and ABCG2 C421A single nucleotide polymorphisms on clinical and pathological outcomes of Kurdish patients with breast cancer.
|
26700668 |
2016 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, a panel of 5 SNPs, namely ABCC2 (-24C > T/rs717620 and c.4544 G > A/rs8187710), ABCG2 (c.421 C > A/rs2231142), ABCB1 (c.3435 C > T/rs1045642) and SLC31A1 (c.-36 + 2451 T > G/rs10981694), was evaluated to assess their association with grade 2-3 OXPN in metastatic CRC patients.
|
30713338 |
2019 |
|
rs1045642
|
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that the C3435T polymorphism of MDR1 may not confer susceptibility to IBD.
|
24449364 |
2014 |
|
rs1045642
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that ABCB1 3435C>T polymorphism is associated with antiemetic treatment efficacy in patients with cancer treated with 5-HT(3) antagonists, particularly in granisetron-treated patients, during the short-term phase of chemotherapy.
|
16338277 |
2005 |
|
rs1045642
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The importance of MDR1 SNPs 2677G > T/A in exon 21 and 3435C > T in exon 26 for cancer susceptibility, however, has not yet been clearly defined.
|
17146660 |
2007 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant association of MDR1 C3435T with CD was observed (CC vs (CT + TT): P = 0.007; OR [95% CI] = 1.58 [1.12-2.23]).
|
16374256 |
2006 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the incidence of C3435T polymorphisms at exon 26 in the MDR-1 gene in 92 women with breast cancer and potential association of altered genotypes with smoking and high body mass index in cancer development among patients.
|
17549370 |
2007 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis provided evidence that MDR1 C3435T polymorphism is associated with a decreased risk of CRC in Asian population.
|
29390571 |
2017 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that ABCB1 gene C3435T, G2677T/A variations and haplotype 3435T-1236T-2677T relate to the risk and clinical outcomes of breast carcinoma and may function as candidate molecular markers of anthracycline chemosensitivity in breast carcinoma.
|
22526155 |
2012 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
C3435T polymorphism of MDR1 gene was analysed by the high resolution melting technique in a group of patients with drug-resistant (n = 106) and drug-responsive epilepsy (n = 67), as well as in non-epileptic children (n = 98) hospitalised at the Department of Neurology, Polish Mother's Memorial Hospital in Lodz.
|
27391700 |
2016 |
|
rs1045642
|
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
CYP3A5*3 and C3435T MDR1 polymorphisms in prognostication of drug-resistant epilepsy in children and adolescents.
|
23984379 |
2013 |
|
rs1045642
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407).
|
23977225 |
2013 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have detected no significant association of C3435T SNP and pediatric CD.
|
27603561 |
2016 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
All the case-control association researches evaluating the role of MDR1 C3435T polymorphism in childhood epilepsy to antiepileptic drugs were identified.
|
24553780 |
2014 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that C3435T polymorphism genotyping and menopausal status at the time of diagnosis might be useful when considering chemotherapy regimens including docetaxel in breast cancer patients.
|
20628376 |
2010 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ABCB1 T-129C, C1236T, G2677T/A and C3435T polymorphisms were genotyped in 210 Japanese epileptics who had been prescribed AEDs, including CBZ, for longer than 2 years.
|
16753003 |
2006 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the T allele carrier of the 34</span>35 C/T polymorphism in the ABCB1 gene in combination with an estrogen receptor-negative status may be an important risk factor for breast cancer development in premenopausal women.
|
25730063 |
2015 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the ABCB1-C3435T gene polymorphism might be a genetic risk factor and a potential biomarker for breast cancer.
|
28039704 |
2017 |