|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, a panel of 5 SNPs, namely ABCC2 (-24C > T/rs717620 and c.4544 G > A/rs8187710), ABCG2 (c.421 C > A/rs2231142), ABCB1 (c.3435 C > T/rs1045642) and SLC31A1 (c.-36 + 2451 T > G/rs10981694), was evaluated to assess their association with grade 2-3 OXPN in metastatic CRC patients.
|
30713338 |
2019 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
With regard to the clinical characteristics of BC, the <i>ABCC2</i> SNPs rs2273697 and rs717620 were found to be significantly associated with age at breast cancer diagnosis and breastfeeding status, while the <i>ABCB1</i> SNP rs1045642 was significantly associated with age at breast cancer diagnosis.
|
31391850 |
2019 |
|
rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the other hand, C allele and CC genotype of C1236T and C3435T, as well as G allele and GG genotype of G2677T/A were more frequent in healthy subjects, implying protective role of these variants in UC.
|
29543864 |
2018 |
|
rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study suggests that CYP2D6*4 and MDR1 3435 C/T gene polymorphisms may be risk factors for UC susceptibility.
|
30551694 |
2018 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G2677T T and C3435T T alleles as well as the TT, CTT and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in our population.
|
29198163 |
2018 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
ABCB1 3435C>T and 2677G>T/A polymorphisms in Polish and Bosnian patients with Crohn's disease - A preliminary report.
|
28759738 |
2017 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis provided evidence that MDR1 C3435T polymorphism is associated with a decreased risk of CRC in Asian population.
|
29390571 |
2017 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the ABCB1-C3435T gene polymorphism might be a genetic risk factor and a potential biomarker for breast cancer.
|
28039704 |
2017 |
|
rs1045642
|
|
Leukopenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations were found between toxicities and gene variants (P<0.05), including neutropenia with ABCB1 (rs1045642) and SLC0B3 (rs4149117 and rs7311358); and diarrhoea with CYP2C9 (rs1057910), CYP2C19 (rs3758581), UGT1A6 (rs4124874) and SLC22A1 (rs72552763).
|
28817838 |
2017 |
|
rs1045642
|
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship between the MDR1 C3435T polymorphism and childhood refractory epilepsy needs further validation.
|
28284049 |
2017 |
|
rs1045642
|
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results indicate that ABCB1 C3435T polymorphism, especially TT genotype, plays an important role in refractory epilepsy.
|
28202008 |
2017 |
|
rs1045642
|
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results indicate that the C3435T polymorphism of MDR1 gene may be associated with the incidence of DRE observed in the Polish population.
|
27534401 |
2017 |
|
rs1045642
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Metaanalysis results showed no significant association between C3435T polymorphism and pediatric ALL risk (TT vs. CC: odds ratio [OR] = 1.20, 95% confidence interval [CI] = 0.95-1.52; CT vs. CC: OR = 1.00, 95% CI = 0.82-1.23; the dominant model: OR = 1.07, 95% CI = 0.89-1.29; the recessive model: OR = 1.17, 95% CI = 0.84-1.62).
|
28845766 |
2017 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggested that ABCB1 rs1045642 and UGT2B7 rs7439366 may affect OXC pharmacokinetics and therapeutic efficacy in Han Chinese patients with epilepsy.
|
28837897 |
2017 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the ABCB1-C3435T gene polymorphism might be a genetic risk factor and a potential biomarker for breast cancer.
|
28039704 |
2017 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have noted that the implication of C3435T</span> variant on the risk of breast cancer was ethnicity-dependent.
|
27580695 |
2016 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to explore the possible influence of CYP2C9 (*2, *3 and IVS8-109 A>T), CYP2C19 (*2, *3 and *17) and ABCB1 (1236C>T, 2677G>A/T and 3435C>T) on phenytoin (PHT) plasma concentrations in 64 Mexican Mestizo (MM) patients with epilepsy currently treated with PHT in mono- (n=25) and polytherapy (n=39).
|
26122019 |
2016 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study was aimed to evaluate the possible effects of ABCB1 C3435T and ABCG2 C421A single nucleotide polymorphisms on clinical and pathological outcomes of Kurdish patients with breast cancer.
|
26700668 |
2016 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
C3435T polymorphism of MDR1 gene was analysed by the high resolution melting technique in a group of patients with drug-resistant (n = 106) and drug-responsive epilepsy (n = 67), as well as in non-epileptic children (n = 98) hospitalised at the Department of Neurology, Polish Mother's Memorial Hospital in Lodz.
|
27391700 |
2016 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have detected no significant association of C3435T SNP and pediatric CD.
|
27603561 |
2016 |
|
rs1045642
|
|
Leukopenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Individuals who were CC homozygotes at MDR1 rs1045642 had lower risk of having methotrexate plasma concentrations >1 μM and leukopenia grade I (odds ratio [OR] = 0.30; 95% CI = 0.13-0.72 and OR = 0.32; 95% CI = 0.14-0.72, respectively).
|
27533339 |
2016 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have noted that the implication of C3435T</span> variant on the risk of breast cancer was ethnicity-dependent.
|
27580695 |
2016 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study was aimed to evaluate the possible effects of ABCB1 C3435T and ABCG2 C421A single nucleotide polymorphisms on clinical and pathological outcomes of Kurdish patients with breast cancer.
|
26700668 |
2016 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |