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rs1045642
|
|
Agnosia for Pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Assays of plasma concentrations of morphine and metabolites (morphine 3-glucuronide and morphine 6-glucuronide) were performed and common polymorphisms in four candidate genes [OPRM1 A118G rs1799971; P-glycoprotein (ABCB1) T3435C (rs1045642) and G2677T/A (rs2032582); COMT Val 158 Met (rs4680)] were analysed.Morphine was titrated by staff in the postanaesthesia care unit (PACU) and in the ward patient-controlled intravenous analgesia was used for 24 h.
|
29474345 |
2018 |
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rs1045642
|
|
Akathisia
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|
0.020 |
GeneticVariation
|
BEFREE |
Marginal associations with akathisia (p=0.039 and p=0.042, respectively) and dystonia (p=0.013 and p=0.034, respectively) were observed for both G2677T/A and C3435T genotypes.
|
20060871 |
2010 |
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rs1045642
|
|
Akathisia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results suggest that individuals with the TT-TT/TA genotypes for the C3435T-G2677T/A polymorphisms of ABCB1 may be pre-disposed to a risk of akathisia.
|
28079463 |
2017 |
|
rs1045642
|
|
Alzheimer's Disease
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|
0.020 |
GeneticVariation
|
BEFREE |
Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing.
|
25273678 |
2014 |
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rs1045642
|
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest that the ABCB1 3435C > T SNP, the 2677G > T/A SNP and 1236T/2677T/3435C haplotype are significantly associated with AD susceptibility.
|
27600024 |
2016 |
|
rs1045642
|
|
Amyloidosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ.
|
21478475 |
2011 |
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rs1045642
|
|
Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
On evaluating higher order gene-gene interaction models by MDR analysis, CYP3A5*3; ABCB11236C>T and ABCB1 2677G>T/A; ABCB1 3435C>T and CYP1B1*3 showed significant association with treatment response, grade 2-4 anemia and dose delay/reduction due to neutropenia (P=0.024, P=0.004, P=0.026), respectively.
|
24704000 |
2014 |
|
rs1045642
|
|
Angina Pectoris, Variant
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no statistically significant association was found between ABCB1 C3435T polymorphism and VAP risk, especially among Asian populations.
|
24328528 |
2014 |
|
rs1045642
|
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant associations were observed between rs1045642 and therapeutic response to etanercept in AS patients.
|
28151874 |
2017 |
|
rs1045642
|
|
Asthenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with a lower risk of asthenia(OR = 0.047; 95 % CI = 0.004–0.493; P = 0.011) and Tallele of ABCB1 C3435T SNP was associated with a lower risk of diarrhea (OR = 0.177; 95 % CI = 0.034–0.919;P = 0.039), and individuals with two copies of GSTT1 gene had a lower risk for asthenia (OR = 0.093; 95 %CI = 0.011–0.794; P = 0.030).
|
23543295 |
2013 |
|
rs1045642
|
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association between CYP2C9*2, CYP2C9*3, VKORC1, CYP4F2*3, ABCB1 C3435T, APOE, CYP2C19*2 and CYP2C19*17 gene polymorphisms and treatment safety in 128 patients diagnosed with atrial fibrillation or venous thromboembolism during the initial first seven months of acenocoumarol therapy.
|
24919870 |
2014 |
|
rs1045642
|
|
Avascular Necrosis of Femur Head
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the relationship between genetic polymorphism in the MDR1 (C3435T, G2677T) and the development of steroid-induced osteonecrosis of femoral head (ONF) in Chinese systemic lupus erythematosus (SLE) patients.
|
18214345 |
2007 |
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rs1045642
|
|
B-CELL MALIGNANCY, LOW-GRADE
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results demonstrate the high frequency of C allele of ABCB1 T3435C in B-CLL patients with Kurdish ethnicity.
|
25586345 |
2015 |
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rs1045642
|
|
B-CELL MALIGNANCY, LOW-GRADE
|
|
0.020 |
GeneticVariation
|
BEFREE |
Taken together, these data indicate that the MDR1 C3435T SNP may carry an increased risk of developing B-CLL, possibly by virtue of decreased protection against P-gp-substrate carcinogens.
|
17085864 |
2007 |
|
rs1045642
|
|
Balkan Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The constitutional genotype frequencies of two SNPs (C3435T and G2677T) in the MDR1 gene in 112 healthy control subjects were investigated and compared with those of 96 patients with BEN.
|
14752243 |
2004 |
|
rs1045642
|
|
Behcet Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
No significant difference was found between genotypic and allelic frequencies of the ABCB1 C3435T polymorphisms in patients with Behçet's disease and healthy volunteers.
|
21218380 |
2011 |
|
rs1045642
|
|
Behcet Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the distribution of MDR1 C3435T polymorphism in 69 patients from the Iranian Azeri Turks group with BD and 92 ethnically sex-matched healthy controls, via the polymerase chain reaction-restriction fragment length polymorphism technique.
|
24898446 |
2014 |
|
rs1045642
|
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association of exon 26 C3435T genetic variants of MDR1 gene with susceptibility to bipolar disorder and serum valproic acid concentration.
|
18165917 |
2009 |
|
rs1045642
|
|
Bodily Pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, patients receiving similar combination therapy (opioid + tricyclic antidepressant) carrying the C allele of rs1045642 displayed 33% fewer body pain sites than patients without that allele, suggesting better pain control.
|
31738228 |
2020 |
|
rs1045642
|
|
BODY ACHE
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, patients receiving similar combination therapy (opioid + tricyclic antidepressant) carrying the C allele of rs1045642 displayed 33% fewer body pain sites than patients without that allele, suggesting better pain control.
|
31738228 |
2020 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that ABCB1 gene C3435T, G2677T/A variations and haplotype 3435T-1236T-2677T relate to the risk and clinical outcomes of breast carcinoma and may function as candidate molecular markers of anthracycline chemosensitivity in breast carcinoma.
|
22526155 |
2012 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, there is limited evidence to indicate that the ABCB1 C3435T and rs2214102 G>A polymorphisms are associated with increased risk of breast cancer.
|
20625815 |
2011 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy.
|
20638924 |
2010 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
MDR1 C3435T polymorphism in Mexican patients with breast cancer.
|
25062490 |
2014 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementation group 1 (ERCC1) rs11615, xeroderma pigmentosum group D (XPD/ERCC2) rs13181, X-ray repair cross complementing group 1 (XRCC1) rs25487, XRCC3 rs1799794, and breast cancer susceptibility gene 1 (BRCA1) rs1799966 from the DNA repair pathway and multiple drug resistance 1 (MDR1/ABCB1) rs1045642 with response to chemotherapy and survival of non-small cell lung cancer (NSCLC) in a Chinese population.
|
24933103 |
2014 |