Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1045642
rs1045642
CUI: C0563625
Disease: Agnosia for Pain
Agnosia for Pain
0.010 GeneticVariation BEFREE Assays of plasma concentrations of morphine and metabolites (morphine 3-glucuronide and morphine 6-glucuronide) were performed and common polymorphisms in four candidate genes [OPRM1 A118G rs1799971; P-glycoprotein (ABCB1) T3435C (rs1045642) and G2677T/A (rs2032582); COMT Val 158 Met (rs4680)] were analysed.Morphine was titrated by staff in the postanaesthesia care unit (PACU) and in the ward patient-controlled intravenous analgesia was used for 24 h. 29474345

2018

dbSNP: rs1045642
rs1045642
CUI: C0392156
Disease: Akathisia
Akathisia
0.020 GeneticVariation BEFREE Marginal associations with akathisia (p=0.039 and p=0.042, respectively) and dystonia (p=0.013 and p=0.034, respectively) were observed for both G2677T/A and C3435T genotypes. 20060871

2010

dbSNP: rs1045642
rs1045642
CUI: C0392156
Disease: Akathisia
Akathisia
0.020 GeneticVariation BEFREE The results suggest that individuals with the TT-TT/TA genotypes for the C3435T-G2677T/A polymorphisms of ABCB1 may be pre-disposed to a risk of akathisia. 28079463

2017

dbSNP: rs1045642
rs1045642
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.020 GeneticVariation BEFREE Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. 25273678

2014

dbSNP: rs1045642
rs1045642
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.020 GeneticVariation BEFREE Our results suggest that the ABCB1 3435C > T SNP, the 2677G > T/A SNP and 1236T/2677T/3435C haplotype are significantly associated with AD susceptibility. 27600024

2016

dbSNP: rs1045642
rs1045642
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.010 GeneticVariation BEFREE In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of . 21478475

2011

dbSNP: rs1045642
rs1045642
CUI: C0002871
Disease: Anemia
Anemia
0.010 GeneticVariation BEFREE On evaluating higher order gene-gene interaction models by MDR analysis, CYP3A5*3; ABCB11236C>T and ABCB1 2677G>T/A; ABCB1 3435C>T and CYP1B1*3 showed significant association with treatment response, grade 2-4 anemia and dose delay/reduction due to neutropenia (P=0.024, P=0.004, P=0.026), respectively. 24704000

2014

dbSNP: rs1045642
rs1045642
CUI: C0002963
Disease: Angina Pectoris, Variant
Angina Pectoris, Variant
0.010 GeneticVariation BEFREE However, no statistically significant association was found between ABCB1 C3435T polymorphism and VAP risk, especially among Asian populations. 24328528

2014

dbSNP: rs1045642
rs1045642
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.010 GeneticVariation BEFREE However, no significant associations were observed between rs1045642 and therapeutic response to etanercept in AS patients. 28151874

2017

dbSNP: rs1045642
rs1045642
CUI: C0004093
Disease: Asthenia
Asthenia
0.010 GeneticVariation BEFREE In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with a lower risk of asthenia(OR = 0.047; 95 % CI = 0.004–0.493; P = 0.011) and Tallele of ABCB1 C3435T SNP was associated with a lower risk of diarrhea (OR = 0.177; 95 % CI = 0.034–0.919;P = 0.039), and individuals with two copies of GSTT1 gene had a lower risk for asthenia (OR = 0.093; 95 %CI = 0.011–0.794; P = 0.030). 23543295

2013

dbSNP: rs1045642
rs1045642
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation
0.010 GeneticVariation BEFREE The aim of this study was to evaluate the association between CYP2C9*2, CYP2C9*3, VKORC1, CYP4F2*3, ABCB1 C3435T, APOE, CYP2C19*2 and CYP2C19*17 gene polymorphisms and treatment safety in 128 patients diagnosed with atrial fibrillation or venous thromboembolism during the initial first seven months of acenocoumarol therapy. 24919870

2014

dbSNP: rs1045642
rs1045642
CUI: C0410480
Disease: Avascular Necrosis of Femur Head
Avascular Necrosis of Femur Head
0.010 GeneticVariation BEFREE This study investigated the relationship between genetic polymorphism in the MDR1 (C3435T, G2677T) and the development of steroid-induced osteonecrosis of femoral head (ONF) in Chinese systemic lupus erythematosus (SLE) patients. 18214345

2007

dbSNP: rs1045642
rs1045642
CUI: C1868683
Disease: B-CELL MALIGNANCY, LOW-GRADE
B-CELL MALIGNANCY, LOW-GRADE
0.020 GeneticVariation BEFREE Our results demonstrate the high frequency of C allele of ABCB1 T3435C in B-CLL patients with Kurdish ethnicity. 25586345

2015

dbSNP: rs1045642
rs1045642
CUI: C1868683
Disease: B-CELL MALIGNANCY, LOW-GRADE
B-CELL MALIGNANCY, LOW-GRADE
0.020 GeneticVariation BEFREE Taken together, these data indicate that the MDR1 C3435T SNP may carry an increased risk of developing B-CLL, possibly by virtue of decreased protection against P-gp-substrate carcinogens. 17085864

2007

dbSNP: rs1045642
rs1045642
CUI: C0004698
Disease: Balkan Nephropathy
Balkan Nephropathy
0.010 GeneticVariation BEFREE The constitutional genotype frequencies of two SNPs (C3435T and G2677T) in the MDR1 gene in 112 healthy control subjects were investigated and compared with those of 96 patients with BEN. 14752243

2004

dbSNP: rs1045642
rs1045642
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.020 GeneticVariation BEFREE No significant difference was found between genotypic and allelic frequencies of the ABCB1 C3435T polymorphisms in patients with Behçet's disease and healthy volunteers. 21218380

2011

dbSNP: rs1045642
rs1045642
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.020 GeneticVariation BEFREE We investigated the distribution of MDR1 C3435T polymorphism in 69 patients from the Iranian Azeri Turks group with BD and 92 ethnically sex-matched healthy controls, via the polymerase chain reaction-restriction fragment length polymorphism technique. 24898446

2014

dbSNP: rs1045642
rs1045642
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.010 GeneticVariation BEFREE We investigated the association of exon 26 C3435T genetic variants of MDR1 gene with susceptibility to bipolar disorder and serum valproic acid concentration. 18165917

2009

dbSNP: rs1045642
rs1045642
CUI: C3890602
Disease: Bodily Pain
Bodily Pain
0.010 GeneticVariation BEFREE Here, patients receiving similar combination therapy (opioid + tricyclic antidepressant) carrying the C allele of rs1045642 displayed 33% fewer body pain sites than patients without that allele, suggesting better pain control. 31738228

2020

dbSNP: rs1045642
rs1045642
CUI: C0741585
Disease: BODY ACHE
BODY ACHE
0.010 GeneticVariation BEFREE Here, patients receiving similar combination therapy (opioid + tricyclic antidepressant) carrying the C allele of rs1045642 displayed 33% fewer body pain sites than patients without that allele, suggesting better pain control. 31738228

2020

dbSNP: rs1045642
rs1045642
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE These results suggest that ABCB1 gene C3435T, G2677T/A variations and haplotype 3435T-1236T-2677T relate to the risk and clinical outcomes of breast carcinoma and may function as candidate molecular markers of anthracycline chemosensitivity in breast carcinoma. 22526155

2012

dbSNP: rs1045642
rs1045642
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE In conclusion, there is limited evidence to indicate that the ABCB1 C3435T and rs2214102 G>A polymorphisms are associated with increased risk of breast cancer. 20625815

2011

dbSNP: rs1045642
rs1045642
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy. 20638924

2010

dbSNP: rs1045642
rs1045642
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE MDR1 C3435T polymorphism in Mexican patients with breast cancer. 25062490

2014

dbSNP: rs1045642
rs1045642
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementation group 1 (ERCC1) rs11615, xeroderma pigmentosum group D (XPD/ERCC2) rs13181, X-ray repair cross complementing group 1 (XRCC1) rs25487, XRCC3 rs1799794, and breast cancer susceptibility gene 1 (BRCA1) rs1799966 from the DNA repair pathway and multiple drug resistance 1 (MDR1/ABCB1) rs1045642 with response to chemotherapy and survival of non-small cell lung cancer (NSCLC) in a Chinese population. 24933103

2014