|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A recent report by Cusi et al showed that the Trp allele of alpha-adducin polymorphism (Gly 460 Trp) is associated with an increased risk of hypertension in whites, which led us to carry out a case-control study to examine whether the same association is observed in the Japanese population.
|
9607391 |
1998 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ADD1 Gly460Trp polymorphism is associated with salt-sensitive hypertension and increased Na-K pump activity in transfected cells.
|
18667944 |
2008 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additional studies have suggested that a polymorphism within exon 10 of the human alpha-adducin gene (Gly-460-Trp) may be associated with hypertension and salt sensitivity.
|
10912756 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584).
|
23122309 |
2012 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Also in humans, a polymorphism of alpha-adducin gene (Gly460Trp) has been found to be significantly associated both to hypertension and salt sensitivity.
|
9678591 |
1998 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An interaction with hypertension in the association between the ADD1 G460W polymorphism and cardiovascular disease merits further testing in additional populations.
|
12052841 |
2002 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Each subject was clinically examined for risk factors for hypertension as well as genotyped for the point mutation Gly460Trp at the alpha-adducin locus on chromosome 4p.
|
10912758 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For any ischemic stroke, there was a significant interaction between the Gly460Trp polymorphism and hypertension.
|
17082469 |
2006 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the Gly460Trp variant was not associated with hypertension in this population.
|
15187197 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variability in the ADD1 (Gly460Trp) and ADD2 (C1797T) subunits of the cytoskeleton protein adducin plays a role in the pathogenesis of hypertension, possibly via changes in intracellular cation concentrations.
|
17301826 |
2007 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hence, no evidence was found to suggest an association between either the alpha-adducin G460W or the ACE I/D polymorphism and hypertension in a careful case-control study.
|
11116113 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In previous studies, an association has been found between the alpha-adducin Gly460Trp polymorphism and salt-sensitive hypertension.
|
11775124 |
2001 |
|
rs4963
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the subgroup analysis by age, older subjects, but not younger subjects, with ADD1 rs4963 po</span>lymorphism showed an increased hypertension risk (OR = 1.19; 95%CI, 1.07-1.32; P = 0.001).
|
28040068 |
2016 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this short editorial review, we summarize the recent experimental, clinical and epidemiological evidence that contributed to our understanding of the pathogenetic mechanisms that lead to hypertension associated with the alpha-adducin Gly460Trp polymorphism and its interaction with ouabain.
|
16207143 |
2005 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, 3 physiologically important candidate gene mutations (angiotensinogen A[-6], alpha-Adducin Gly460Trp, and G-Protein beta(3)-subunit C825T) were examined for their association with hypertension status in a sample of 904 African Americans from Jackson, Mississippi.
|
10856280 |
2000 |
|
rs4963
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension.
|
23509723 |
2013 |
|
rs16843452
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension.
|
23509723 |
2013 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension.
|
20145305 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, the Gly460Trp genotype of the alpha-adducin gene (ADD1) is associated with erythrocyte sodium transport and increases tubular sodium reabsorption and risk for hypertension.
|
12924618 |
2003 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our case-control study and the following meta-analysis failed to provide evidence for the genetic association of alpha-adducin gene G460W polymorphism with hypertension.
|
19960031 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the α-adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.
|
30552709 |
2019 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis failed to provide evidence for the genetic association of α-adducin gene Gly460Trp polymorphism with hypertension.
|
20927398 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that the Gly460Trp polymorphism might increase the risk of hypertension in Chinese populations, especially in Han Chinese.
|
21228790 |
2011 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have shown an association between the alpha-adducin Gly460Trp polymorphism and salt-sensitive hypertension.
|
15326084 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Since inflammatory mechanisms may be involved in pathophysiology of hypertension and in endothelial dysfunction and atherosclerosis through reactive oxygen species, the baseline urinary excretion of inflammatory and oxidative stress markers in a subgroup of adolescents stratified according to <i>ADD1</i>(alpha adducin) rs4961 genotypes was assessed.
|
31760884 |
2020 |