|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Since inflammatory mechanisms may be involved in pathophysiology of hypertension and in endothelial dysfunction and atherosclerosis through reactive oxygen species, the baseline urinary excretion of inflammatory and oxidative stress markers in a subgroup of adolescents stratified according to <i>ADD1</i>(alpha adducin) rs4961 genotypes was assessed.
|
31760884 |
2020 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the α-adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.
|
30552709 |
2019 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity.
|
27480094 |
2017 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ADD1 G460W-dominant model for the G allele was significantly associated with hypertension of IgAN patients (P = 0.001, Pc = 0.031 and OR = 1.37).
|
24271554 |
2014 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584).
|
23122309 |
2012 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that the Gly460Trp polymorphism might increase the risk of hypertension in Chinese populations, especially in Han Chinese.
|
21228790 |
2011 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension.
|
20145305 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our case-control study and the following meta-analysis failed to provide evidence for the genetic association of alpha-adducin gene G460W polymorphism with hypertension.
|
19960031 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis failed to provide evidence for the genetic association of α-adducin gene Gly460Trp polymorphism with hypertension.
|
20927398 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension.
|
19145769 |
2009 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the Adducin-1 (ADD1) G460W nonsense single nucleotide polymorphism (SNP) have previously been associated to hypertension, whereas their association with preeclampsia (PE) and gestational hypertension (GH) is still controversial.
|
19443911 |
2009 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly460Trp variant of the alpha-adducin gene has been associated with renal sodium retention and salt-sensitive hypertension.
|
18458162 |
2008 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ADD1 Gly460Trp polymorphism is associated with salt-sensitive hypertension and increased Na-K pump activity in transfected cells.
|
18667944 |
2008 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The alpha-adducin (ADD1) Gly460Trp polymorphism has been associated with hypertension and response to diuretic therapy, but controversy exists.
|
18657677 |
2008 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The alpha-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure.
|
17472579 |
2007 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variability in the ADD1 (Gly460Trp) and ADD2 (C1797T) subunits of the cytoskeleton protein adducin plays a role in the pathogenesis of hypertension, possibly via changes in intracellular cation concentrations.
|
17301826 |
2007 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension.
|
17984662 |
2007 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For any ischemic stroke, there was a significant interaction between the Gly460Trp polymorphism and hypertension.
|
17082469 |
2006 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this short editorial review, we summarize the recent experimental, clinical and epidemiological evidence that contributed to our understanding of the pathogenetic mechanisms that lead to hypertension associated with the alpha-adducin Gly460Trp polymorphism and its interaction with ouabain.
|
16207143 |
2005 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ACE I/D, alpha-adducin Gly460Trp and aldosterone synthase -344C/T polymorphisms interact to influence systolic blood pressure in Chinese, suggesting that these genes might indeed predispose to hypertension, especially in an ecogenetic context characterized by a high salt intake.
|
15097233 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have shown an association between the alpha-adducin Gly460Trp polymorphism and salt-sensitive hypertension.
|
15326084 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study focused on 3 genetic polymorphisms that have previously been implicated in hypertension: the alpha-adducin (ADD1/Gly460Trp), beta1-adrenoreceptor (ADRB1/Arg389Gly), and G-protein beta3 subunit (GNB3/C825T) gene polymorphisms.
|
15055253 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the Gly460Trp polymorphism of ADD-1 is not associated with hypertension.
|
15608390 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the Gly460Trp variant was not associated with hypertension in this population.
|
15187197 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, the Gly460Trp genotype of the alpha-adducin gene (ADD1) is associated with erythrocyte sodium transport and increases tubular sodium reabsorption and risk for hypertension.
|
12924618 |
2003 |