|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly460Trp variant of alpha-adducin is not associated with hypertension in white Anglo-Australians.
|
10371374 |
1999 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Each subject was clinically examined for risk factors for hypertension as well as genotyped for the point mutation Gly460Trp at the alpha-adducin locus on chromosome 4p.
|
10912758 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The alpha-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure.
|
17472579 |
2007 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our case-control study and the following meta-analysis failed to provide evidence for the genetic association of alpha-adducin gene G460W polymorphism with hypertension.
|
19960031 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hence, no evidence was found to suggest an association between either the alpha-adducin G460W or the ACE I/D polymorphism and hypertension in a careful case-control study.
|
11116113 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the Gly460Trp variant was not associated with hypertension in this population.
|
15187197 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In previous studies, an association has been found between the alpha-adducin Gly460Trp polymorphism and salt-sensitive hypertension.
|
11775124 |
2001 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variability in the ADD1 (Gly460Trp) and ADD2 (C1797T) subunits of the cytoskeleton protein adducin plays a role in the pathogenesis of hypertension, possibly via changes in intracellular cation concentrations.
|
17301826 |
2007 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension.
|
17984662 |
2007 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The alpha-adducin (ADD1) Gly460Trp polymorphism has been associated with hypertension and response to diuretic therapy, but controversy exists.
|
18657677 |
2008 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis failed to provide evidence for the genetic association of α-adducin gene Gly460Trp polymorphism with hypertension.
|
20927398 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ADD1 G460W-dominant model for the G allele was significantly associated with hypertension of IgAN patients (P = 0.001, Pc = 0.031 and OR = 1.37).
|
24271554 |
2014 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, the Gly460Trp genotype of the alpha-adducin gene (ADD1) is associated with erythrocyte sodium transport and increases tubular sodium reabsorption and risk for hypertension.
|
12924618 |
2003 |
|
rs4963
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the subgroup analysis by age, older subjects, but not younger subjects, with ADD1 rs4963 po</span>lymorphism showed an increased hypertension risk (OR = 1.19; 95%CI, 1.07-1.32; P = 0.001).
|
28040068 |
2016 |
|
rs4963
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension.
|
23509723 |
2013 |
|
rs1255327081
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two point mutations in MHS alpha- (F316Y) and beta- (Q529R) adducin genes have been shown to be associated with hypertension in genetic crosses of MHS and MNS rats.
|
9678591 |
1998 |
|
rs16843452
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension.
|
23509723 |
2013 |
|
rs372777117
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two point mutations in MHS alpha- (F316Y) and beta- (Q529R) adducin genes have been shown to be associated with hypertension in genetic crosses of MHS and MNS rats.
|
9678591 |
1998 |