rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Sunitinib therapy for melanoma patients with KIT mutations.
|
22261812 |
2012 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification.
|
21690468 |
2011 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
KIT as a therapeutic target in metastatic melanoma.
|
21642685 |
2011 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy--case report and review of the literature.
|
19996579 |
2010 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
We have identified the first human melanoma cell line with an endogenous L576P mutation, the most common KIT mutation in melanoma ( approximately 30-40%).
|
19671763 |
2009 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
KIT gene mutations and copy number in melanoma subtypes.
|
18980976 |
2008 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition.
|
17372901 |
2007 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Somatic activation of KIT in distinct subtypes of melanoma.
|
16908931 |
2006 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.
|
15790786 |
2005 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours.
|
11276010 |
2001 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
|
9438854 |
1998 |
rs121913513
|
|
C |
0.760 |
CausalMutation |
CLINVAR |
Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.
|
7530509 |
1995 |
rs1057519710
|
|
T |
0.710 |
CausalMutation |
CLINVAR |
Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
|
23775962 |
2013 |
rs1057519710
|
|
C |
0.710 |
CausalMutation |
CLINVAR |
KIT as a therapeutic target in metastatic melanoma.
|
21642685 |
2011 |
rs1057519710
|
|
C |
0.710 |
CausalMutation |
CLINVAR |
Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification.
|
21690468 |
2011 |
rs1057519710
|
|
T |
0.710 |
CausalMutation |
CLINVAR |
KIT as a therapeutic target in metastatic melanoma.
|
21642685 |
2011 |
rs1057519710
|
|
T |
0.710 |
CausalMutation |
CLINVAR |
Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure.
|
20088873 |
2010 |
rs1057519710
|
|
C |
0.710 |
CausalMutation |
CLINVAR |
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor.
|
18955458 |
2008 |
rs1057519710
|
|
C |
0.710 |
CausalMutation |
CLINVAR |
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.
|
15790786 |
2005 |
rs1057519710
|
|
C |
0.710 |
CausalMutation |
CLINVAR |
Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours.
|
11276010 |
2001 |
rs1057519710
|
|
C |
0.710 |
CausalMutation |
CLINVAR |
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
|
9438854 |
1998 |
rs1057519710
|
|
C |
0.710 |
CausalMutation |
CLINVAR |
Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.
|
7530509 |
1995 |
rs1057519703
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
The GIST of targeted therapy for malignant melanoma.
|
24531699 |
2014 |
rs1057519703
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
Transcriptome sequencing of melanocytic nevi and melanomas from Grm1 transgenic mice to determine melanoma driver mutations.
|
24661573 |
2014 |