|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our novel findings show the effects of periostin on recruitment of activated fibroblasts through FAK-integrin signaling and on their collagen fibril formation specific to healing after AMI.
|
18208976 |
2008 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The latter mechano-regulatory circuit was also observed in TAFs but in a subtype-specific fashion, because SCC-TAFs exhibited higher FAK (pY397), β1 expression, and ERK1/2 (pT202/Y204) than ADC-TAFs.
|
25280968 |
2015 |
|
Adenocarcinoma
|
0.030 |
Biomarker
|
group |
LHGDN |
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells.
|
18263593 |
2008 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
To determine the role of elevated FAK expression in facilitating epidermal growth factor (EGF)-stimulated human adenocarcinoma (A549) cell motility, antisense oligonucleotides were used to reduce FAK protein expression >75%.
|
11585739 |
2001 |
|
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to assess FAK/Src/PXN protein expression in both primary and liver metastatic sites of colorectal adenocarcinoma (CRC).
|
29135089 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of c-MET and FAK in lung adenocarcinoma cells was also reduced by ACTA2-targeting siRNAs and shRNAs, and was accompanied by a loss of mesenchymal characteristics.
|
23995859 |
2013 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the impact of <i>Nf1</i> loss on LUAD development using a CRISPR/Cas9 platform in a murine model of <i>Kras</i>-mutant LUAD We discovered that <i>Nf1</i> deactivation is associated with Fak1 hyperactivation and phosphoserine aminotransferase 1 (Psat1) upregulation in mice.
|
31036704 |
2019 |
|
Adenocarcinoma of pancreas
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
FAK gene silencing suppresses anoikis resistance in pancreatic adenocarcinoma cells.
|
15118593 |
2004 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, in an in vitro model for human colon cancer progression there was a copy number gain of the fak gene during conversion from adenoma to carcinoma, which was associated with increased pp125FAK protein expression.
|
10523844 |
1999 |
|
Adult Astrocytic Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared to normal brain, the expression of p125FAK was elevated in malignant astrocytic tumor biopsies from patient samples.
|
11069767 |
2000 |
|
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The utilization of FAK‑deficient cells demonstrated that the participation of FAK was obligatory for heparin‑dependent fibrosarcoma cell adhesion (p<0.05).
|
27572115 |
2016 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, microarray gene expression analysis can be effective in establishing genes affected in response to FAK inhibitor alone and in response to combination of Y15 with temozolomide that is important for glioblastoma therapy.
|
23387973 |
2014 |
|
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this report, we found that naringin can specifically inhibit the kinase activity of FAK and suppress the FAK<sup>p-Try397</sup>and its downstream pathway in glioblastoma cells.
|
27125297 |
2017 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Also, knockdown- or pharmacological agent-based attenuation of EGFR, FAK or Graf (ARHGAP26)/small GTPase-mediated pathways markedly mitigated the aggressiveness of glioblastoma cells.
|
26377974 |
2015 |
|
Adult Glioblastoma
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
Moreover, the dimeric bicyclic ligand induced cell detachment and inhibited FAK phosphorylation in U-373 MG glioblastoma cells.
|
31556442 |
2019 |
|
Adult Liposarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Screening assays identified several previously unrecognized targets including PTK2 and KIT in liposarcoma.
|
29132397 |
2017 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thyroid hormone-mediated regulation of lipocalin 2 through the Met/FAK pathway in liver cancer.
|
25940797 |
2015 |
|
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of DLC1 and p-FAK Y397 were negatively correlated.
|
22272086 |
2011 |
|
Adult Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A basal state of pp125FAK tyrosine phosphorylation was observed in T and B lymphocytes, and its expression level was in general augmented among human T- and B-cell leukemia/lymphoma lines.
|
7692878 |
1993 |
|
Adult Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, total and phosphorylated AKT, ERK, and FAK, which have been shown to be important drivers for meningioma cell proliferation, were markedly lower in silvestrol-treated Ben-Men-1 cells.
|
28610844 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further studies revealed that SRPX2 expression in PDAC tissues significantly correlated with the phosphorylation levels of FAK, indicating that FAK dependent pathway may be account for the effect of SRPX2 on cell migration and invasion in PDAC.
|
26191169 |
2015 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Peptide *CRRETAWAC* antagonizes fibronectin-induced cytokine synthesis and secretion of airway smooth muscle cells via the inhibition of FAK and p38 MAPK, and is a potential agent for the therapy of asthma.
|
28402030 |
2017 |
|
Astrocytoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Finally, we analyzed the effects of intermediate filament gene transfer on FAK phosphorylation in SF-126 astrocytoma cells.
|
10029102 |
1999 |
|
Astrocytoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Compared to normal brain, the expression of p125FAK was elevated in malignant astrocytic tumor biopsies from patient samples.
|
11069767 |
2000 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |