|
Myocardial Infarction
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
After Gin-Re treatment, the phosphorylation of FAK, PI3K p110α and Akt was enhanced in MI rats, while PI3K p110β showed no difference compared with the MI group.
|
31599782 |
2020 |
|
Tumour budding
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We then verified that the interaction between LN-5γ2 and integrin β1 promotes the TB of CRC via the activation of FAK and Yes-associated proteins (YAP).
|
31676872 |
2020 |
|
Presenile dementia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We also characterised the effects of hippocampal CA1 injection of p17 on epidermal growth factor receptor-1 (EGFR1) expression linked to our murine model of dementia. p17 strongly induced angiogenesis of HbMEC (migration, tube formation and spheroid growth). p17 concomitantly increased phosphorylation of EGFR1 as well as down-stream intermediates ERK1/2, FAK, PLC-γ and PKC-β whilst an inhibitor peptide of EGFR, blocked cell signalling and angiogenesis.
|
30390010 |
2019 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Porcine Hemagglutinating Encephalomyelitis Virus Activation of the Integrin α5β1-FAK-Cofilin Pathway Causes Cytoskeletal Rearrangement To Promote Its Invasion of N2a Cells.
|
30541856 |
2019 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that FAK-ERK signaling may be involved in OPN-enhanced autophagy in the EBI phase after SAH.
|
31461955 |
2019 |
|
Niemann-Pick Disease, Type C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ova-induced apoptosis correlated with increased Bax/Bcl-xL ratio while NPC motility and colony formation inhibition were associated with reduced expression of p-FAK, p-PXN, F-actin, and Slug proteins and increased E-cadherin.
|
30668347 |
2019 |
|
Tumor necrosis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, high expression of cytoplasmic ph-FAK Y<sup>925</sup> was associated with decreased tumour grade (P < .001), less involved lymph node (P = .020), molecular subtypes (P < .001), decreased tumour necrosis (P < .001), low Klintrup-Mäkinen grade (P < .001), decreased CD4+ T-cells (P = .006), decreased CD138+ plasma cells (P = .034), endocrine therapy (P < .001), chemotherapy (P = .048), and improved cancer specific survival (P = .044).
|
30981841 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FAK, Src and p-PXN expression was significantly decreased in liver metastasis compared to matched paired primary CRCs (p<0.01).
|
29135089 |
2019 |
|
Dementia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We also characterised the effects of hippocampal CA1 injection of p17 on epidermal growth factor receptor-1 (EGFR1) expression linked to our murine model of dementia. p17 strongly induced angiogenesis of HbMEC (migration, tube formation and spheroid growth). p17 concomitantly increased phosphorylation of EGFR1 as well as down-stream intermediates ERK1/2, FAK, PLC-γ and PKC-β whilst an inhibitor peptide of EGFR, blocked cell signalling and angiogenesis.
|
30390010 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, targeting the PTK2-TBK1-SQSTM1 axis may represent a novel therapeutic intervention for neurodegenerative diseases with TARDBP proteinopathies.<b>Abbreviations</b>: ALP: macroautophagy/autophagy lysosomal pathway; ALS: amyotrophic lateral sclerosis; ATXN2: ataxin 2; BafA1: bafilomycin A<sub>1</sub>; cCASP3: cleaved caspase 3; CSNK2: casein kinase 2; FTLD: frontotemporal lobar degeneration; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; OPTN: optineurin; PTK2/FAK: PTK2 protein tyrosine kinase 2; SQSTM1/p62: sequestosome 1; TARDBP/TDP-43: TAR DNA binding protein; TBK1: TANK binding kinase 1; ULK1: unc-51 like autophagy activating kinase 1; UPS: ubiquitin-proteasome system.
|
31690171 |
2019 |
|
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to assess FAK/Src/PXN protein expression in both primary and liver metastatic sites of colorectal adenocarcinoma (CRC).
|
29135089 |
2019 |
|
Ductal Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results of the present study show that membranous and nuclear ph-FAK Y<sup>397</sup> and cytoplasmic ph-FAK Y<sup>925</sup> were associated with prognosis in patients with primary operable ductal breast cancer.
|
30981841 |
2019 |
|
TDP-43 Proteinopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies.
|
31690171 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data not only support a crucial role for the C-terminus in ADAM17 activation and downstream profibrotic responses to HG, but also highlight FAK as a potential alternative therapeutic target for diabetic nephropathy.
|
29361535 |
2018 |
|
Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, total and phosphorylated AKT, ERK, and FAK, which have been shown to be important drivers for meningioma cell proliferation, were markedly lower in silvestrol-treated Ben-Men-1 cells.
|
28610844 |
2018 |
|
Respiratory Distress Syndrome, Adult
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, developmental differences in FAK expression during inflammatory injury serve to preserve neonatal pulmonary endothelial barrier function compared with that of adults and suggest that intrinsic differences in the immature versus pulmonary endothelium, especially relative to FAK1 phosphorylation, may contribute to the improved outcomes of children with ARDS.
|
29597831 |
2018 |
|
Disorder of tendon
|
0.010 |
Biomarker
|
group |
BEFREE |
It could be attributed to the cell morphology changes and reduced FAK and ERK1/2 activation in the degenerative microenvironment of tendinopathy.
|
30510582 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
Our findings highlight an important role for miR-125a-5p regulation and its downstream target pFAK for imatinib resistance in GIST. pFAK and FAK may have prognostic values in GIST.
|
30149002 |
2018 |
|
Adult Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, total and phosphorylated AKT, ERK, and FAK, which have been shown to be important drivers for meningioma cell proliferation, were markedly lower in silvestrol-treated Ben-Men-1 cells.
|
28610844 |
2018 |
|
precancerous lesions
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Targeting FAK by either RNAi or pharmacologic inhibitors effectively blocked cell growth, colony formation, and invasion into 3D collagen matrices.<b>Conclusions:</b> CTTN and FAK emerge as powerful predictors of laryngeal cancer risk and recurrence risk beyond histologic grading.<b>Impact:</b> Our work supports the applicability of IHC CTTN and FAK as complementary markers for risk stratification in patients with laryngeal precancerous lesions.
|
29654156 |
2018 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In summary, this study shows that fucoidan protects against <i>p</i>-cresol-induced cellular senescence in MSCs through activation of the FAK-Akt-TWIST pathway and suggests that fucoidan could be used in conjunction with functional MSC-based therapies in the treatment of CKD.
|
29642406 |
2018 |
|
Tendinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
It could be attributed to the cell morphology changes and reduced FAK and ERK1/2 activation in the degenerative microenvironment of tendinopathy.
|
30510582 |
2018 |
|
Meningioma, benign, no ICD-O subtype
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, total and phosphorylated AKT, ERK, and FAK, which have been shown to be important drivers for meningioma cell proliferation, were markedly lower in silvestrol-treated Ben-Men-1 cells.
|
28610844 |
2018 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Peptide *CRRETAWAC* antagonizes fibronectin-induced cytokine synthesis and secretion of airway smooth muscle cells via the inhibition of FAK and p38 MAPK, and is a potential agent for the therapy of asthma.
|
28402030 |
2017 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN.
|
28881794 |
2017 |