PTK2, protein tyrosine kinase 2, 5747

N. diseases: 205; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.550 GeneticVariation disease UNIPROT
CUI: C0278883
Disease: Metastatic melanoma
Metastatic melanoma 		0.300 GeneticVariation disease UNIPROT
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Taken together, the data indicate that this structurally conserved human T-cell pp125FAK likely functions in T- and B-cell lineages, and its altered expression in human lymphocyte tumor cell lines may contribute to their transformed phenotype. 7692878 1993
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.020 AlteredExpression disease BEFREE A basal state of pp125FAK tyrosine phosphorylation was observed in T and B lymphocytes, and its expression level was in general augmented among human T- and B-cell leukemia/lymphoma lines. 7692878 1993
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.010 AlteredExpression group BEFREE A basal state of pp125FAK tyrosine phosphorylation was observed in T and B lymphocytes, and its expression level was in general augmented among human T- and B-cell leukemia/lymphoma lines. 7692878 1993
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.010 AlteredExpression disease BEFREE A basal state of pp125FAK tyrosine phosphorylation was observed in T and B lymphocytes, and its expression level was in general augmented among human T- and B-cell leukemia/lymphoma lines. 7692878 1993
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma 		0.010 AlteredExpression disease BEFREE A basal state of pp125FAK tyrosine phosphorylation was observed in T and B lymphocytes, and its expression level was in general augmented among human T- and B-cell leukemia/lymphoma lines. 7692878 1993
CUI: C2004493
Disease: Leukemia, B-Cell
Leukemia, B-Cell 		0.010 AlteredExpression disease BEFREE A basal state of pp125FAK tyrosine phosphorylation was observed in T and B lymphocytes, and its expression level was in general augmented among human T- and B-cell leukemia/lymphoma lines. 7692878 1993
CUI: C1261473
Disease: Sarcoma
Sarcoma 		0.020 GeneticVariation group BEFREE We have isolated a human homologue of the FAK gene from primary sarcomas and looked for FAK mRNA in 49 human tissue samples, including paired normal and neoplastic samples. 8105266 1993
CUI: C4551686
Disease: Malignant neoplasm of soft tissue
Malignant neoplasm of soft tissue 		0.020 GeneticVariation group BEFREE We have isolated a human homologue of the FAK gene from primary sarcomas and looked for FAK mRNA in 49 human tissue samples, including paired normal and neoplastic samples. 8105266 1993
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.300 Biomarker phenotype BEFREE The up-regulation of paxillin independently or in concert with p125FAK as shown in this study indicates its significant role as a potential marker of metastasis in renal carcinoma cells. 9023046 1996
CUI: C0919989
Disease: Metastatic renal carcinoma
Metastatic renal carcinoma 		0.010 AlteredExpression disease BEFREE Integrin expression on cell adhesion function and up-regulation of P125FAK and paxillin in metastatic renal carcinoma cells. 9023046 1996
CUI: C1368683
Disease: Epithelioma
Epithelioma 		0.010 Biomarker disease BEFREE The alteration of integrin subunits alpha 2, alpha 3, alpha V, beta 1, as well as p125FAK and paxillin may contribute to the pathogenicity and/or metastatic propensity of renal epithelial tumors. 9023046 1996
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.020 PosttranslationalModification disease BEFREE Finally, we analyzed the effects of intermediate filament gene transfer on FAK phosphorylation in SF-126 astrocytoma cells. 10029102 1999
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.010 PosttranslationalModification disease BEFREE Finally, we analyzed the effects of intermediate filament gene transfer on FAK phosphorylation in SF-126 astrocytoma cells. 10029102 1999
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.350 Biomarker disease BEFREE Here we used in situ hybridization to confirm chromosome 8q as the genomic location of the human fak gene and report that elevation of pp125FAK protein in cell lines derived from invasive squamous cell carcinomas is accompanied by gains in copy number of the fak gene in all cases examined. 10523844 1999
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 Biomarker disease BEFREE In addition, in an in vitro model for human colon cancer progression there was a copy number gain of the fak gene during conversion from adenoma to carcinoma, which was associated with increased pp125FAK protein expression. 10523844 1999
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE In addition, in an in vitro model for human colon cancer progression there was a copy number gain of the fak gene during conversion from adenoma to carcinoma, which was associated with increased pp125FAK protein expression. 10523844 1999
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 AlteredExpression group BEFREE In addition, in an in vitro model for human colon cancer progression there was a copy number gain of the fak gene during conversion from adenoma to carcinoma, which was associated with increased pp125FAK protein expression. 10523844 1999
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE These data demonstrate for the first time that p125FAK promotes tumor cell proliferation in vivo, and that the underlying mechanism is not associated with a reduction in apoptosis. 11069767 2000
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.020 AlteredExpression disease BEFREE Compared to normal brain, the expression of p125FAK was elevated in malignant astrocytic tumor biopsies from patient samples. 11069767 2000
CUI: C1321865
Disease: Juvenile astrocytoma
Juvenile astrocytoma 		0.010 AlteredExpression disease BEFREE Compared to normal brain, the expression of p125FAK was elevated in malignant astrocytic tumor biopsies from patient samples. 11069767 2000
CUI: C1332183
Disease: Adult Astrocytic Tumor
Adult Astrocytic Tumor 		0.010 AlteredExpression disease BEFREE Compared to normal brain, the expression of p125FAK was elevated in malignant astrocytic tumor biopsies from patient samples. 11069767 2000
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.030 AlteredExpression group BEFREE To determine the role of elevated FAK expression in facilitating epidermal growth factor (EGF)-stimulated human adenocarcinoma (A549) cell motility, antisense oligonucleotides were used to reduce FAK protein expression >75%. 11585739 2001
CUI: C0017638
Disease: Glioma
Glioma 		0.100 GeneticVariation disease LHGDN Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G. 12054581 2002