|
Endometriosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
Therefore, the miR-142-3p/KLF9/VEGFA signalling pathway may be a potential target in endometriosis treatment.
|
31425004 |
2019 |
|
Endometriosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated promotion of ectopic lesion establishment by Klf9 null endometrium in a mouse model of endometriosis.
|
25904015 |
2015 |
|
Endometriosis
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Eutopic endometrium from women with endometriosis had reduced expression of KLF9 mRNA together with those of PGR-B, WNT4, WNT2, and DKK1.
|
22259059 |
2012 |
|
Thyroid Diseases
|
0.310 |
Biomarker
|
group |
BEFREE |
Our findings suggest that the TR-KLF9 axis is responsible for the hematopoietic dysfunction and might be exploited for the development of novel therapeutic interventions for thyroid diseases.
|
28972010 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tet-On inducible KLF9 expression was established for the evaluation of the effects of KLF9 on cell proliferation, apoptosis, and xenograft tumor growth in nude mice.
|
24737412 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KLF9 is the core effector protein that might suppress tumor growth.
|
27956179 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Krüppel-like factor 9 (KLF9) has been found to play suppressive roles in several types of tumor.
|
25641762 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Krüppel-like factor 9 (KLF9) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.
|
26210742 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Krüppel-like factor 9 (KLF9) has prodifferentiation and tumor suppression functions in several types of cancers.
|
31782614 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, we aim to investigate the effect of lentivirus-mediated knockdown of Krüppel-like factor 9 (KLF9) on cell viability and tumor growth in ovarian cancer.
|
25216959 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
At the molecular level, krüppel-like factor 9 (KLF9), a tumor suppressor gene, was identified as a potential target of miR-570 in lung cancer cells.
|
26045791 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Importantly, re-constitution of KLF9 expression inhibited glioma cell proliferation and tumor growth in vivo.
|
25305446 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
KLF9 influences the expression of uterine epithelial genes through mechanisms likely involving its transcriptional activator and repressor functions and which may underlie altered tumor biology with aberrant KLF9 expression.
|
18783612 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Krüppel-like factor 9 (KLF9) plays critical roles in several types of tumor.
|
29107105 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Remarkably, ectopic expression of KLF9 was sufficient to delay the onset of tumors and to promote regression of the established tumors in vivo, suggesting that KLF9 plays a critical role in HCC development and that pharmacological or genetic activation of KLF9 may have potential in the treatment of HCC.
|
25242357 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Kruppel-like factor 9 (KLF9), a transcription factor, is critical for the inhibition of growth and development of tumors, whereas its effects in pancreatic cancer remains unclear.
|
30542730 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results show for the first time that KLF9 has differentiating and tumor-suppressing functions in tumor-initiating stem cells.
|
21280156 |
2011 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Knocking down the expression of KLF9 also promoted the tumorigenesis in the PDAC mouse xneograft model.
|
29621541 |
2018 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results indicate that KLF9 may be involved in the carcinogenesis of human colorectal cancer.
|
18477211 |
2008 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, upregulation of miR-889 promotes tumorigenesis in vitro, and KLF9 protein levels are also reduced.
|
30849540 |
2019 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We established for the first time a genome-wide map of KLF9-regulated targets in human glioblastoma stemlike cells and show that KLF9 functions as a transcriptional repressor and thereby regulates multiple signaling pathways involved in oncogenesis and stem cell regulation.
|
25288800 |
2014 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The functional relevance of attenuated KLF9 expression in endometrial carcinogenesis was further evaluated in the human endometrial carcinoma cell line Ishikawa by siRNA targeting.
|
21543766 |
2011 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Kruppel-like factors (KLFs) are involved in various biological processes; emerging studies have indicated that KLF9 plays a critical role in regulating tumorigenesis.
|
24737412 |
2014 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Restoration of miR-141-3p suppresses the expression of the transcription factor KLF9 in PC-3 and accelerates prostate tumorigenesis via targeted binding with its 3'-UTR.
|
27956179 |
2017 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Results show KLF9 to be a haploinsufficient suppressor of colon tumorigenesis in Apc(Min/+) mice in part, by repression of ISG15 and the latter's antiapoptotic function.
|
26210742 |
2015 |