KLF9, Kruppel like factor 9, 687

N. diseases: 77; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.030 Biomarker disease BEFREE Chromatin immunoprecipitation with anti-BTEB1 antibody demonstrated BTEB1 recruitment to the proximal GC-rich containing SLPI promoter region (-97 to -86) in human endometrial carcinoma (Hec1A) cells overexpressing BTEB1. 16384861 2006
CUI: C0729353
Disease: Subfertility
Subfertility 		0.010 AlteredExpression disease BEFREE We previously demonstrated that basic transcription element binding protein-1 (BTEB1), a transcription factor of the Krüppel-like family, is a functional PR-interacting protein, based on the subfertility phenotype and reduced P sensitivity of uterine PR target genes, on BTEB1 null mutation. 16384861 2006
CUI: C1153706
Disease: Endometrial adenocarcinoma
Endometrial adenocarcinoma 		0.010 Biomarker disease BEFREE Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. 17717078 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE KLF9 influences the expression of uterine epithelial genes through mechanisms likely involving its transcriptional activator and repressor functions and which may underlie altered tumor biology with aberrant KLF9 expression. 18783612 2008
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE These results indicate that KLF9 may be involved in the carcinogenesis of human colorectal cancer. 18477211 2008
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 AlteredExpression phenotype BEFREE Krüppel-like factor 9 (KLF9) is a transcriptional regulator of uterine endometrial cell proliferation, adhesion and differentiation; processes essential for pregnancy success and which are subverted during tumorigenesis. 18783612 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 Biomarker disease BEFREE These results indicate that KLF9 may be involved in the carcinogenesis of human colorectal cancer. 18477211 2008
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.030 AlteredExpression disease BEFREE Over-expression of KLF9 in the human endometrial cancer cell line HEC-1-A alters cell morphology, proliferative indices, and differentiation, when compared to KLF9 under-expressing HEC-1-A cells. 18783612 2008
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium 		0.020 AlteredExpression disease BEFREE Over-expression of KLF9 in the human endometrial cancer cell line HEC-1-A alters cell morphology, proliferative indices, and differentiation, when compared to KLF9 under-expressing HEC-1-A cells. 18783612 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.020 Biomarker group LHGDN Downregulation of Krüppel-like factor 9 in human colorectal cancer. 18477211 2008
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.020 Biomarker disease BEFREE These results indicate that KLF9 may be involved in the carcinogenesis of human colorectal cancer. 18477211 2008
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.330 Biomarker disease CTD_human Molecular evidence for differences in endometrium in severe versus mild endometriosis. 21063030 2011
CUI: C0269102
Disease: Endometrioma
Endometrioma 		0.300 Biomarker disease CTD_human Molecular evidence for differences in endometrium in severe versus mild endometriosis. 21063030 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Our results show for the first time that KLF9 has differentiating and tumor-suppressing functions in tumor-initiating stem cells. 21280156 2011
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 AlteredExpression phenotype BEFREE The functional relevance of attenuated KLF9 expression in endometrial carcinogenesis was further evaluated in the human endometrial carcinoma cell line Ishikawa by siRNA targeting. 21543766 2011
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.040 Biomarker disease BEFREE We also show that KLF9 regulates GBM neurosphere cells by binding to the Notch1 promoter and suppressing Notch1 expression and downstream signaling. 21280156 2011
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.040 Biomarker disease BEFREE We also show that KLF9 regulates GBM neurosphere cells by binding to the Notch1 promoter and suppressing Notch1 expression and downstream signaling. 21280156 2011
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.030 AlteredExpression disease BEFREE The functional relevance of attenuated KLF9 expression in endometrial carcinogenesis was further evaluated in the human endometrial carcinoma cell line Ishikawa by siRNA targeting. 21543766 2011
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium 		0.020 Biomarker disease BEFREE Deregulated expression of a number of Sp proteins has been associated with multiple types of human tumors, but a role for KLF9 in endometrial cancer development and/or progression is unknown. 21543766 2011
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.330 AlteredExpression disease BEFREE Eutopic endometrium from women with endometriosis had reduced expression of KLF9 mRNA together with those of PGR-B, WNT4, WNT2, and DKK1. 22259059 2012
CUI: C0005910
Disease: Body Weight
Body Weight 		0.300 Biomarker phenotype CTD_human Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. 22344221 2012
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.010 AlteredExpression disease BEFREE The higher expression of KLF 9 and KLF10 has been verified in the replication cohort with AATD-related end-stage lung emphysema and liver cirrhosis. 22621770 2012
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.010 AlteredExpression disease BEFREE The higher expression of KLF 9 and KLF10 has been verified in the replication cohort with AATD-related end-stage lung emphysema and liver cirrhosis. 22621770 2012
CUI: C0221757
Disease: alpha 1-Antitrypsin Deficiency
alpha 1-Antitrypsin Deficiency 		0.010 AlteredExpression disease BEFREE The higher expression of KLF 9 and KLF10 has been verified in the replication cohort with AATD-related end-stage lung emphysema and liver cirrhosis. 22621770 2012
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance 		0.010 AlteredExpression disease BEFREE Whether loss of KLF9 expression contributes to progesterone resistance of eutopic endometrium of women with endometriosis is unknown. 22259059 2012