KLF9, Kruppel like factor 9, 687

N. diseases: 77; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1135196
Disease: Heart Failure, Diastolic
Heart Failure, Diastolic
0.300 Biomarker disease CTD_human In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction. 29556499 2018
CUI: C1153706
Disease: Endometrial adenocarcinoma
Endometrial adenocarcinoma
0.010 Biomarker disease BEFREE Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. 17717078 2007
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression phenotype BEFREE Krüppel-like factor 9 (KLF9) is a transcriptional regulator of uterine endometrial cell proliferation, adhesion and differentiation; processes essential for pregnancy success and which are subverted during tumorigenesis. 18783612 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE KLF9 influences the expression of uterine epithelial genes through mechanisms likely involving its transcriptional activator and repressor functions and which may underlie altered tumor biology with aberrant KLF9 expression. 18783612 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.020 Biomarker group BEFREE Krüppel-like factor 9 (KLF9) is known to be a tumor suppressor gene in colorectal tumors and glioblastoma; however, the functional status and significance of KLF9 in hepatocellular carcinoma (HCC) is unclear. 25242357 2014
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.040 Biomarker disease BEFREE Krüppel-like factor 9 (KLF9) is known to be a tumor suppressor gene in colorectal tumors and glioblastoma; however, the functional status and significance of KLF9 in hepatocellular carcinoma (HCC) is unclear. 25242357 2014
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.040 Biomarker disease BEFREE Krüppel-like factor 9 (KLF9) is known to be a tumor suppressor gene in colorectal tumors and glioblastoma; however, the functional status and significance of KLF9 in hepatocellular carcinoma (HCC) is unclear. 25242357 2014
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.030 Biomarker disease BEFREE Krüppel-like factor 9 (KLF9) is known to be a tumor suppressor gene in colorectal tumors and glioblastoma; however, the functional status and significance of KLF9 in hepatocellular carcinoma (HCC) is unclear. 25242357 2014
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.030 Biomarker disease BEFREE Krüppel-like factor 9 (KLF9) is known to be a tumor suppressor gene in colorectal tumors and glioblastoma; however, the functional status and significance of KLF9 in hepatocellular carcinoma (HCC) is unclear. 25242357 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Krüppel-like factor 9 (KLF9) has been found to play suppressive roles in several types of tumor. 25641762 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Krüppel-like factor 9 (KLF9) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine. 26210742 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE KLF9 is the core effector protein that might suppress tumor growth. 27956179 2017
CUI: C1335302
Disease: Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma
0.020 AlteredExpression disease BEFREE KLF9 expression was found to be a valuable prognostic factor for patients with pancreatic ductal adenocarcinoma. 28668877 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE Krüppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion. 29107105 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Krüppel-like factor 9 (KLF9) plays critical roles in several types of tumor. 29107105 2018
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.030 Biomarker disease BEFREE Krüppel-like factor 9 and histone deacetylase inhibitors synergistically induce cell death in glioblastoma stem-like cells. 30348136 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.030 Biomarker disease BEFREE Krüppel-like factor 9 and histone deacetylase inhibitors synergistically induce cell death in glioblastoma stem-like cells. 30348136 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Kruppel-like factor 9 (KLF9), a transcription factor, is critical for the inhibition of growth and development of tumors, whereas its effects in pancreatic cancer remains unclear. 30542730 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE KLF9 may have potential diagnostic and therapeutic values in this type of cancer. 30542730 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.030 Biomarker group BEFREE KLF9 may have potential diagnostic and therapeutic values in this type of cancer. 30542730 2018
CUI: C0025202
Disease: melanoma
melanoma
0.010 Biomarker disease BEFREE Klf9 deficiency inhibited premalignant melanocytic hyperplasia in Braf<sup>CA</sup> mice but did not affect formation and growth of Braf<sup>CA</sup>/Pten<sup>-/-</sup> primary melanomas. 30664687 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 AlteredExpression phenotype BEFREE KLF9 overexpression significantly stimulated the proliferation and metastasis of MGC-803 and BGC-823 cells. 30746617 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 Biomarker phenotype BEFREE KLF9 suppresses gastric cancer cell invasion and metastasis through transcriptional inhibition of MMP28. 30913394 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Krüppel-like factor 9 (KLF9) has prodifferentiation and tumor suppression functions in several types of cancers. 31782614 2020
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.020 Biomarker disease BEFREE Krüppel-like factor 9 (<i>KLF9</i>) belongs to a family of transcriptional regulators and its role in BC has not been fully investigated. 31819488 2019