TFPI, tissue factor pathway inhibitor, 7035

N. diseases: 230; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.370 Biomarker disease BEFREE TF, TFPI, and APC had the same variation characteristics in the DVT subgroup compared with the no DVT subgroup. 29196248 2018
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.370 Biomarker disease BEFREE The area under ROC curve of TFPI-1 was 0.905 (95% CI, 0.842~0.967) or 0.828 (95% CI, 0.742~0.915) for predicting DVT or metastasis (<i>P</i> < 0.001, resp.). 28246607 2017
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.370 GeneticVariation disease BEFREE Association of genetic polymorphisms with plasma TFPI level: Boon or curse for DVT patients - Study from India. 28810169 2017
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.370 GeneticVariation disease BEFREE This study was undertaken to examine whether the genetic polymorphisms in TFPI are associated with the plasma TFPI levels and risk for DVT. 20523161 2009
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.370 GeneticVariation disease BEFREE Our results indicate the presence of potent repressor sequences between -1999 and -345 in the TFPI promoter and suggest that the TFPI T-287C promoter polymorphism might be a risk factor for DVT. 17931693 2008
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.370 Therapeutic disease CTD_human Comparison of anticoagulant effects on vein grafts between human TFPI gene transfection and aspirin oral administration. 18480984 2008
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.370 Biomarker disease BEFREE We conclude that patients suffering from acute deep venous thrombosis express significantly higher concentrations of tissue factor pathway inhibitor than patients without deep venous thrombosis. 18600090 2008
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.370 GeneticVariation disease BEFREE These results provide evidence for a relationship between venous thrombosis and total TFPI level as a possible risk factor, whereas they do not support a link between DVT and mutations in the nine exons of the TFPI gene. 11380428 2001
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.320 Biomarker disease BEFREE Mechanistically, these mice displayed increased thrombin generation, resistance to activated protein C and TFPI, and improved fibrin network. 29317453 2018
CUI: C0042487
Disease: Venous Thrombosis
Venous Thrombosis 		0.320 Therapeutic phenotype CTD_human Comparison of anticoagulant effects on vein grafts between human TFPI gene transfection and aspirin oral administration. 18480984 2008
CUI: C0042487
Disease: Venous Thrombosis
Venous Thrombosis 		0.320 GeneticVariation phenotype LHGDN Analysis of a T-287C polymorphism in the tissue factor pathway inhibitor gene and identification of a repressor element in the promoter. 17931693 2008
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.320 AlteredExpression disease LHGDN Our objective was to study the effect of OC on the two main determinants of the APC-resistance test, free protein S and free tissue factor pathway inhibitor (TFPI). 18067603 2008
CUI: C0042487
Disease: Venous Thrombosis
Venous Thrombosis 		0.320 GeneticVariation phenotype LHGDN These results indicate that the TFPI -33T->C and -399C->T polymorphisms are significantly associated with venous thrombosis in the presence of other risk factors, especially APS, and may be clinically relevant in patients who are prone to hypercoagulability. 17762532 2007
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.320 Biomarker disease CTD_human Hormone replacement therapy and acquired resistance to activated protein C: results of a randomized, double-blind, placebo-controlled trial. 11703344 2001
CUI: C0001883
Disease: Airway Obstruction
Airway Obstruction 		0.300 Therapeutic group CTD_human Intratracheal administration of TFPI limits airway obstruction, improves gas exchange, and prevents mortality in rats with sulfur mustard-analog-induced acute lung injury. 23727623 2013
CUI: C0003129
Disease: Anoxemia
Anoxemia 		0.300 Therapeutic phenotype CTD_human Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. 23727623 2013
CUI: C0003130
Disease: Anoxia
Anoxia 		0.300 Therapeutic phenotype CTD_human Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. 23727623 2013
CUI: C0008301
Disease: Choking
Choking 		0.300 Therapeutic phenotype CTD_human Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. 23727623 2013
CUI: C0242184
Disease: Hypoxia
Hypoxia 		0.300 Therapeutic phenotype CTD_human Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. 23727623 2013
CUI: C0700292
Disease: Hypoxemia
Hypoxemia 		0.300 Therapeutic phenotype CTD_human Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. 23727623 2013
CUI: C0087031
Disease: Juvenile-Onset Still Disease
Juvenile-Onset Still Disease 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C3495559
Disease: Juvenile arthritis
Juvenile arthritis 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C3714758
Disease: Juvenile psoriatic arthritis
Juvenile psoriatic arthritis 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C4552091
Disease: Polyarthritis, Juvenile, Rheumatoid Factor Negative
Polyarthritis, Juvenile, Rheumatoid Factor Negative 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C4704862
Disease: Polyarthritis, Juvenile, Rheumatoid Factor Positive
Polyarthritis, Juvenile, Rheumatoid Factor Positive 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009