|
Liver Cirrhosis
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
It obtained accuracy rates of 89.76% and 89.13% in distinguishing between small HCC and hepatic cirrhosis (CIR) groups as well as between HCC and CIR groups, superior to 87.99% and 80.35% by k-TSP.
|
30965135 |
2019 |
|
Malignant neoplasm of prostate
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Similarly, gene-gene interaction of VEGF and TSP1 polymorphisms increased risk of prostate cancer in additive manner (OR = 6.00, P = 0.03), although the TSP1 polymorphism itself was not associated with the risk.
|
17917789 |
2009 |
|
Malignant neoplasm of prostate
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No association was observed between any of the TSP1 genotypes and PCa risk or severity; however, subjects carrying one copy of the MMP9 T allele exhibited threefold higher risk of developing PCa (OR = 2.86; P = 0.004).
|
17175378 |
2007 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
Recently, the TSP-1 N700S variant was proposed to be a new genetic predictor for myocardial infarction (MI) in American population, but the hypothesis was not verified in two other populations.
|
15140581 |
2004 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
LHGDN |
Association of thrombospondin-1 gene polymorphisms with myocardial infarction in a Chinese Han population.
|
18208671 |
2008 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
A functional single nucleotide polymorphism in the TSP-1 gene (TSP-1 A2210G) is a risk factor for familial premature myocardial infarction.
|
21883885 |
2011 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
Our data suggests that the presence of thrombospondin-1 (rs2228262) and thrombospondin-2 (rs8089) variants need not be considered a risk for coronary artery disease or myocardial infarction among South Indians.
|
21762961 |
2011 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction.
|
15007078 |
2004 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size.
|
16684956 |
2006 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
The THBS-1 variant allele was not associated with an altered risk of premature CAD or MI.
|
12482844 |
2002 |
|
Heart Diseases
|
0.210 |
GeneticVariation
|
group |
BEFREE |
A study focusing on candidate genes associated with premature cardiovascular disease discovered that missense variations in the thrombospondin 1 and 4 genes were associated with premature coronary artery disease, while a mutation in the non-coding region of a thrombospondin 2 gene imparts protection from developing heart disease.
|
12537090 |
2003 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we validated two previously reported CpG sites (cg05886626 in THBS1, and cg24838345 in MTSS1) for their potential relation to atherosclerosis and cancer diseases, using several different approaches: CpG site methylation, gene expression, and plasma protein level determinations.
|
26829059 |
2015 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we validated two previously reported CpG sites (cg05886626 in THBS1, and cg24838345 in MTSS1) for their potential relation to atherosclerosis and cancer diseases, using several different approaches: CpG site methylation, gene expression, and plasma protein level determinations.
|
26829059 |
2015 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, we validated two previously reported CpG sites (cg05886626 in THBS1, and cg24838345 in MTSS1) for their potential relation to atherosclerosis and cancer diseases, using several different approaches: CpG site methylation, gene expression, and plasma protein level determinations.
|
26829059 |
2015 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Transcriptional repressor Id1 is overexpressed in many malignancies including melanoma, and Id1 targets include tumor suppressor genes TSP1, CDKN2A (p16) and CDKN1A (p21), which are frequently epigenetically silenced in cancer.
|
20484992 |
2010 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It has been argued that CIN contributes to cancer initiation because chromosome loss can unmask a mutated tumor suppressor (TSP) gene.
|
15105448 |
2004 |
|
Herpes Simplex Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Novel deletion in glycoprotein G forms a cluster and causes epidemiologic spread of herpes simplex virus type 2 infection.
|
23861013 |
2013 |
|
HTLV-I Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To examine whether other factors influence the outcome of HTLV-I infection in patients with HAM/TSP and ACs, we analyzed spontaneous Tax expression and cytokine production in peripheral blood mononuclear cells using flow cytometry.
|
12660926 |
2003 |
|
HTLV-I Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The patterns of differential cytokine induction and sensitization to apoptosis displayed by Tax1 and Tax2 may reflect differences relating to the heightened neuropathogenicity associated with HTLV-1 infection and the development of HAM/TSP.
|
17121800 |
2007 |
|
HTLV-I Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It was observed that: (i) 14bpDI genotype is a risk factor for HTLV-1 infection, while the 14bpDD and +3142CC genotypes were associated with protection against infection; (ii) the +3142C allele and the +3003CT and +3142CC genotypes were associated with susceptibility, while 14bpII and +3003TT genotypes were associated with protection against HAM/TSP development; and (iii) the 14bpII, +3010CC, +3142GG and +3187AA genotypes were associated with lower HTLV-1 proviral load compared to respective counterpart genotypes.
|
27449667 |
2016 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The splice junctions for the tax-rex mRNA described in cases of HTLV-I-induced adult T-cell leukemia (position 5183 of the envelope and position 7302 of the pX region) were identical in three TSP/HAM cases studied.
|
1995955 |
1991 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The human T cell leukemia virus-1 (HTLV-1) is a retrovirus that causes adult T cell leukemia (ATL) and neurological disorder, the tropical spastic paraparesis (HAM/TSP).
|
11244044 |
2001 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The splice junctions for the tax-rex mRNA described in cases of HTLV-I-induced adult T-cell leukemia (position 5183 of the envelope and position 7302 of the pX region) were identical in three TSP/HAM cases studied.
|
1995955 |
1991 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases.
|
29499169 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This clone produced larger primary tumors and an increase in the occurrence of metastases relative to control transfectants, suggesting the participation of a previously understudied region of TSP1 in the regulation of tumor progression.
|
7527299 |
1994 |