THBS1, thrombospondin 1, 7057

N. diseases: 480; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0375023
Disease: Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 		0.100 AlteredExpression disease BEFREE Human respiratory syncytial virus glycoprotein G expressed from a recombinant vaccinia virus vector protects mice against live-virus challenge. 3773052 1986
CUI: C3714753
Disease: RETINOSCHISIS 1, X-LINKED, JUVENILE
RETINOSCHISIS 1, X-LINKED, JUVENILE 		0.020 Biomarker disease BEFREE Recombinant vaccinia virus vectors were constructed which expressed the major surface glycoprotein G of human respiratory syncytial (RS) virus. 3773052 1986
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. 2475502 1989
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.100 Biomarker disease BEFREE Collectively, these results suggest that immune activation in HAM/TSP, in contrast to ATL, is virally driven by the transactivation and coordinate expression of IL-2 and IL-2R alpha. 2367534 1990
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia 		0.100 Biomarker disease BEFREE Collectively, these results suggest that immune activation in HAM/TSP, in contrast to ATL, is virally driven by the transactivation and coordinate expression of IL-2 and IL-2R alpha. 2367534 1990
CUI: C0030481
Disease: Tropical Spastic Paraparesis
Tropical Spastic Paraparesis 		0.100 Biomarker disease BEFREE All PCR-positive cases were seropositive, including 4 cases of tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) (4/4), and one case each of myasthenia gravis (1/7) and multiple sclerosis (1/8). 2112526 1990
CUI: C0375023
Disease: Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 		0.100 Biomarker disease BEFREE An antigenic site (represented by 15 amino acids, residues 174 to 188, designated peptide 12) of the large glycoprotein G of respiratory syncytial virus was demonstrated to be subgroup specific in peptide enzyme-linked immunosorbent assay tests with murine monoclonal antibodies and human postinfection sera. 1697913 1990
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.060 Biomarker disease BEFREE All PCR-positive cases were seropositive, including 4 cases of tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) (4/4), and one case each of myasthenia gravis (1/7) and multiple sclerosis (1/8). 2112526 1990
CUI: C3714753
Disease: RETINOSCHISIS 1, X-LINKED, JUVENILE
RETINOSCHISIS 1, X-LINKED, JUVENILE 		0.020 Biomarker disease BEFREE Previous work has shown that the glycoprotein G of a subgroup A RS virus expressed from a recombinant vaccinia virus provides significant protection against homologous but not heterologous subgroup virus challenge. 1697126 1990
CUI: C0026896
Disease: Myasthenia Gravis
Myasthenia Gravis 		0.010 Biomarker disease BEFREE All PCR-positive cases were seropositive, including 4 cases of tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) (4/4), and one case each of myasthenia gravis (1/7) and multiple sclerosis (1/8). 2112526 1990
CUI: C0020097
Disease: HTLV-I Infections
HTLV-I Infections 		0.100 Biomarker group BEFREE Tropical spastic paraparesis/human T-cell leukemia-lymphoma virus type I (HTLV-I)-associated myelopathy (TSP/HAM) is a chronic neurological illness epidemiologically associated with HTLV-I infection. 1995955 1991
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.100 GeneticVariation disease BEFREE The splice junctions for the tax-rex mRNA described in cases of HTLV-I-induced adult T-cell leukemia (position 5183 of the envelope and position 7302 of the pX region) were identical in three TSP/HAM cases studied. 1995955 1991
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia 		0.100 GeneticVariation disease BEFREE The splice junctions for the tax-rex mRNA described in cases of HTLV-I-induced adult T-cell leukemia (position 5183 of the envelope and position 7302 of the pX region) were identical in three TSP/HAM cases studied. 1995955 1991
CUI: C0030481
Disease: Tropical Spastic Paraparesis
Tropical Spastic Paraparesis 		0.100 Biomarker disease BEFREE In situ hybridization detection of HTLV-I RNA in peripheral blood mononuclear cells of TSP/HAM patients and their spouses. 1849984 1991
CUI: C0266999
Disease: Vesicular Stomatitis
Vesicular Stomatitis 		0.060 Biomarker disease BEFREE The control virus, Ad5VSV, was also a recombinant which contained the gene for vesicular stomatitis virus glycoprotein G inserted into the E3 region of Ad5d1E3. 1704821 1991
CUI: C1707758
Disease: Direct Contact Transmission Infection
Direct Contact Transmission Infection 		0.010 Biomarker disease BEFREE These findings suggest that the pathogenesis of HAM/TSP depends on direct infection of neural or immune elements within the spinal cord. 1745362 1991
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.100 Biomarker disease BEFREE These two T-cell lines established will serve as substrate for further comparative studies on TSP and ATL isolates. 1520534 1992
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia 		0.100 Biomarker disease BEFREE These two T-cell lines established will serve as substrate for further comparative studies on TSP and ATL isolates. 1520534 1992
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia 		0.100 Biomarker disease BEFREE Human T cell lymphotrophic virus type I (HTLV-I) is the etiologic agent of adult T cell lymphoma/leukemia (ATLL) and tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). 1517966 1992
CUI: C0030481
Disease: Tropical Spastic Paraparesis
Tropical Spastic Paraparesis 		0.100 Biomarker disease BEFREE Cell surface phenotype of in vitro proliferating lymphocytes in HTLV-I-associated myelopathy (HAM/TSP). 1560112 1992
CUI: C0030481
Disease: Tropical Spastic Paraparesis
Tropical Spastic Paraparesis 		0.100 GeneticVariation disease BEFREE Random integration of the proviruses was observed in asymptomatic HTLV-1 carriers and patients with HTLV-1-associated myelopathy (HAM/TSP). 1498321 1992
CUI: C0030481
Disease: Tropical Spastic Paraparesis
Tropical Spastic Paraparesis 		0.100 Biomarker disease BEFREE Therefore, it is unlikely that the central nervous system tissue damage in HAM/TSP is a consequence of productive infection of HTLV-I in the CNS tissue. 1571019 1992
CUI: C0030481
Disease: Tropical Spastic Paraparesis
Tropical Spastic Paraparesis 		0.100 Biomarker disease BEFREE Human T cell lymphotrophic virus type I (HTLV-I) is the etiologic agent of adult T cell lymphoma/leukemia (ATLL) and tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). 1517966 1992
CUI: C0034494
Disease: Rabies (disorder)
Rabies (disorder) 		0.100 GeneticVariation disease BEFREE Canarypox virus was used as a vector for the rabies glycoprotein G gene. 1351126 1992
CUI: C0276199
Disease: Canarypox (disorder)
Canarypox (disorder) 		0.010 Biomarker disease BEFREE Canarypox virus was used as a vector for the rabies glycoprotein G gene. 1351126 1992